Opsoclonus-myoclonus syndrome associated with herpes simplex encephalitis

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dc.contributor.authorAfonso, C.O.M.
dc.contributor.authorCampos, M.L.S.
dc.contributor.authorMaia, Ferdinand Gilbert Saraiva da Silva
dc.contributor.authorCampêlo, C.L.C.
dc.contributor.authorCamilo, A.F.C.
dc.contributor.authorCorreia, Carlos Eduardo Rocha
dc.contributor.authorFernandes, José Veríssimo
dc.contributor.authorFigueiredo, Marcelo Marinho de
dc.contributor.authorSilva, R.A.
dc.date.accessioned2023-05-29T17:23:27Z
dc.date.available2023-05-29T17:23:27Z
dc.date.issued2015-10-15
dc.description.resumoBackground: Opsoclonus-myoclonus ataxia is a rare neurologic syn drome, often paraneoplastic in origin, but reported in association with various infections. Little is known about adult-onset opsoclonus myoclonus syndrome (OMS) outside of individual case reports Objective: Describe a case of herpes-simplex virus 1 encephalitis presenting as opsoclonus-myoclonus ataxia Patients and methods: A 35 year-old woman, with no known comorbidities, developed a headache with nausea and vomiting, without fever or nuchal rigidity. In the following 48-hours, she presented an altered mental status, opsoclonus and myoclonus and was admitted to hospital. Lumbar puncture: 40 cells (60% mononu clear), protein 140 mg/dL and a normal glucose. Gram stain and culture for bacteria and fungi were negative. A PCR for herpes simplex virus was positive. Brain MRI: normal. Chest, Abdomen and Pelvis CT: no signs of neoplasia. Results: The patient received intra-venous acyclovir for 21 days, with resolution of symptoms Conclusion: OMS is an uncommon presentation of infections of central nervous system. Its fame extends further to the fact that OMS can be a harbinger of occult malignancy. The Adult-onset presentation is rare. Paraneoplastic and parainfectious causes (particularly virus) are common; however, more often OMS in adults occurs after systemic infection. After this report, HSV1 infection should be considered in OMS cases. We described the first case of OMS secondary to Herpes-Simplex Virus 1 infection.pt_BR
dc.identifier.citationCORREIA, Carlos Eduardo Rocha; et al. Opsoclonus-myoclonus syndrome associated with herpes simplex encephalitis. Journal Of The Neurological Sciences, [S.l.], v. 357, p. 56, out. 2015. Elsevier BV. Disponível em: https://www.sciencedirect.com/science/article/pii/S0022510X15007169?via%3Dihub. Acesso em: 29 mio 2023. DOI: http://dx.doi.org/10.1016/j.jns.2015.08.220pt_BR
dc.identifier.doi10.1016/j.jns.2015.08.220.
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/52559
dc.languagept_BRpt_BR
dc.publisherJournal Of The Neurological Sciencespt_BR
dc.subjectopsoclonus-myoclonuspt_BR
dc.subjectencephalitispt_BR
dc.subjectparaneoplasticpt_BR
dc.titleOpsoclonus-myoclonus syndrome associated with herpes simplex encephalitispt_BR
dc.typearticlept_BR

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