Recognition memory reconsolidation requires hippocampal Zif268

dc.contributor.authorGonzalez, Maria Carolina
dc.contributor.authorRossato, Janine I.
dc.contributor.authorRadiske, Andressa
dc.contributor.authorReis, Marina Pádua
dc.contributor.authorCammarota, Martín Pablo
dc.date.accessioned2019-12-18T15:14:06Z
dc.date.available2019-12-18T15:14:06Z
dc.date.issued2019-11-12
dc.description.resumoObject recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.pt_BR
dc.identifier.citationGONZALEZ, M. C.; ROSSATO, J. I.; RADISKE, A.; REIS, M. P.; CAMMAROTA, M. Recognition memory reconsolidation requires hippocampal Zif268. Sci Rep., [s. l.], v. 9, p. 16620, nov. 2019. Doi: 10.1038/s41598-019-53005-8. Disponível em: https://www-ncbi-nlm-nih-gov.ez18.periodicos.capes.gov.br/pmc/articles/PMC6851087/. Acesso em: 18 dez. 2019.pt_BR
dc.identifier.doi10.1038/s41598-019-53005-8
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/28209
dc.languageenpt_BR
dc.subjectNeurophysiologypt_BR
dc.subjectLearning and memorypt_BR
dc.titleRecognition memory reconsolidation requires hippocampal Zif268pt_BR
dc.typearticlept_BR

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