Recognition memory reconsolidation requires hippocampal Zif268

Gonzalez, Maria Carolina; Rossato, Janine I.; Radiske, Andressa; Reis, Marina Pádua; Cammarota, Martín Pablo

Recognition memory reconsolidation requires hippocampal Zif268

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dc.contributor.author	Gonzalez, Maria Carolina
dc.contributor.author	Rossato, Janine I.
dc.contributor.author	Radiske, Andressa
dc.contributor.author	Reis, Marina Pádua
dc.contributor.author	Cammarota, Martín Pablo
dc.date.accessioned	2019-12-18T15:14:06Z
dc.date.available	2019-12-18T15:14:06Z
dc.date.issued	2019-11-12
dc.description.resumo	Object recognition memory (ORM) serves to distinguish familiar items from novel ones. Reconsolidation is the process by which active memories are updated. The hippocampus is engaged in ORM reconsolidation through a mechanism involving induction of long-term potentiation (LTP). The transcription factor Zif268 is essential for hippocampal LTP maintenance and has been frequently associated with memory processes. However, its possible involvement in ORM reconsolidation has not been determined conclusively. Using Zif268 antisense oligonucleotides in combination with behavioural, biochemical and electrophysiological tools in rats, we found that hippocampal Zif268 is necessary to update ORM through reconsolidation but not to retrieve it or keep it stored. Our results also suggest that knocking down hippocampal Zif268 during ORM reconsolidation deletes the active recognition memory trace.	pt_BR
dc.identifier.citation	GONZALEZ, M. C.; ROSSATO, J. I.; RADISKE, A.; REIS, M. P.; CAMMAROTA, M. Recognition memory reconsolidation requires hippocampal Zif268. Sci Rep., [s. l.], v. 9, p. 16620, nov. 2019. Doi: 10.1038/s41598-019-53005-8. Disponível em: https://www-ncbi-nlm-nih-gov.ez18.periodicos.capes.gov.br/pmc/articles/PMC6851087/. Acesso em: 18 dez. 2019.	pt_BR
dc.identifier.doi	10.1038/s41598-019-53005-8
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/28209
dc.language	en	pt_BR
dc.subject	Neurophysiology	pt_BR
dc.subject	Learning and memory	pt_BR
dc.title	Recognition memory reconsolidation requires hippocampal Zif268	pt_BR
dc.type	article	pt_BR