Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus
| dc.contributor.author | Soares, Bruno Lobão | |
| dc.contributor.author | Figueiredo, Cláudia P. | |
| dc.contributor.author | Antunes, Victor L.S. | |
| dc.contributor.author | Moreira, Eduardo L.G. | |
| dc.contributor.author | Mello, Nelson de | |
| dc.contributor.author | Medeiros, Rodrigo Medeiros | |
| dc.contributor.author | Giunta, Gabriella Di | |
| dc.contributor.author | Linhares, Marcelo | |
| dc.contributor.author | Lin, Katia | |
| dc.contributor.author | Mazzuco, Tânia L. | |
| dc.contributor.author | Prediger, Rui D.S. | |
| dc.contributor.author | Walz, Roger | |
| dc.date.accessioned | 2020-09-23T20:55:48Z | |
| dc.date.available | 2020-09-23T20:55:48Z | |
| dc.date.issued | 2011-04 | |
| dc.description.resumo | The glucose-dependent insulinotropic peptide receptor (GIPR) has been implicated with neuroplasticity and may be related to epilepsy. GIPR expression was analyzed by immunohistochemistry in the hippocampus (HIP) and neocortex (Cx) of rats undergoing pilocarpine induced status epilepticus (Pilo-SE), and in three young male patients with left mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) treated surgically. A combined GIPR immunohistochemistry and Fluoro-Jade staining was carried out to investigate the association between the GIPR expression and neuronal degeneration induced by Pilo-SE. GIPR was expressed in the cytoplasm of neurons from the HIP CA subfields, dentate gyrus (DG) and Cx of animals and human samples. The GIPR expression after the Pilo-SE induction increases significantly in the HIP after 1 h and 5 days, but not after 12 h or 50 days. In the Cx, the GIPR expression increases after 1 h, 12 h and 5 days, but not 50 days after the Pilo-SE. The expression of GIPR 12 h after Pilo- SE was inversely proportional to the Fluoro-Jade staining intensity. In the human tissue, GIPR expression patterns were similar to those observed in chronic Pilo-SE animals. No Fluoro-Jade stained cells were observed in the human sample. GIPR is expressed in human HIP and Cx. There was a time and region dependent increase of GIPR expression in the HIP and Cx after Pilo-SE that was inversely associated to neuronal degeneration. | pt_BR |
| dc.identifier.citation | SOARES, Bruno Lobão et al. Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides (New York, N.Y. 1980), v. 32, p. 781-789, 2011. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0196978110005383>. Acesso em: 23 mar. 2018. https://doi.org/10.1016/j.peptides.2010.12.010 | pt_BR |
| dc.identifier.doi | 10.1016/j.peptides.2010.12.010 | |
| dc.identifier.issn | 0196-9781 | |
| dc.identifier.uri | https://repositorio.ufrn.br/jspui/handle/123456789/30196 | |
| dc.language | pt_BR | pt_BR |
| dc.publisher | Elsevier | pt_BR |
| dc.rights | Acesso Aberto | pt_BR |
| dc.subject | Mesial temporal lobe epilepsy | pt_BR |
| dc.subject | Hippocampal sclerosis | pt_BR |
| dc.subject | Glucose-dependent insulinotropic peptide receptor | pt_BR |
| dc.title | Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus | pt_BR |
| dc.type | article | pt_BR |
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