Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus

dc.contributor.authorSoares, Bruno Lobão
dc.contributor.authorFigueiredo, Cláudia P.
dc.contributor.authorAntunes, Victor L.S.
dc.contributor.authorMoreira, Eduardo L.G.
dc.contributor.authorMello, Nelson de
dc.contributor.authorMedeiros, Rodrigo Medeiros
dc.contributor.authorGiunta, Gabriella Di
dc.contributor.authorLinhares, Marcelo
dc.contributor.authorLin, Katia
dc.contributor.authorMazzuco, Tânia L.
dc.contributor.authorPrediger, Rui D.S.
dc.contributor.authorWalz, Roger
dc.date.accessioned2020-09-23T20:55:48Z
dc.date.available2020-09-23T20:55:48Z
dc.date.issued2011-04
dc.description.resumoThe glucose-dependent insulinotropic peptide receptor (GIPR) has been implicated with neuroplasticity and may be related to epilepsy. GIPR expression was analyzed by immunohistochemistry in the hippocampus (HIP) and neocortex (Cx) of rats undergoing pilocarpine induced status epilepticus (Pilo-SE), and in three young male patients with left mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) treated surgically. A combined GIPR immunohistochemistry and Fluoro-Jade staining was carried out to investigate the association between the GIPR expression and neuronal degeneration induced by Pilo-SE. GIPR was expressed in the cytoplasm of neurons from the HIP CA subfields, dentate gyrus (DG) and Cx of animals and human samples. The GIPR expression after the Pilo-SE induction increases significantly in the HIP after 1 h and 5 days, but not after 12 h or 50 days. In the Cx, the GIPR expression increases after 1 h, 12 h and 5 days, but not 50 days after the Pilo-SE. The expression of GIPR 12 h after Pilo- SE was inversely proportional to the Fluoro-Jade staining intensity. In the human tissue, GIPR expression patterns were similar to those observed in chronic Pilo-SE animals. No Fluoro-Jade stained cells were observed in the human sample. GIPR is expressed in human HIP and Cx. There was a time and region dependent increase of GIPR expression in the HIP and Cx after Pilo-SE that was inversely associated to neuronal degeneration.pt_BR
dc.identifier.citationSOARES, Bruno Lobão et al. Glucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticus. Peptides (New York, N.Y. 1980), v. 32, p. 781-789, 2011. Disponível em: <https://www.sciencedirect.com/science/article/abs/pii/S0196978110005383>. Acesso em: 23 mar. 2018. https://doi.org/10.1016/j.peptides.2010.12.010pt_BR
dc.identifier.doi10.1016/j.peptides.2010.12.010
dc.identifier.issn0196-9781
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/30196
dc.languagept_BRpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMesial temporal lobe epilepsypt_BR
dc.subjectHippocampal sclerosispt_BR
dc.subjectGlucose-dependent insulinotropic peptide receptorpt_BR
dc.titleGlucose-dependent insulinotropic peptide receptor expression in the hippocampus and neocortex of mesial temporal lobe epilepsy patients and rats undergoing pilocarpine induced status epilepticuspt_BR
dc.typearticlept_BR

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