Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses

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dc.contributor.authorReis, Bruna Zavarize
dc.contributor.authorFernandes, Alan Lins
dc.contributor.authorMurai, Igor Hisashi
dc.contributor.authorPereira, Rosa Maria Rodrigues
dc.date.accessioned2024-03-01T21:37:30Z
dc.date.available2024-03-01T21:37:30Z
dc.date.issued2022-04
dc.description.resumoPurpose: To evaluate whether the prognostic nutritional index (PNI) is related to the oxygen therapy requirement at hospital admission and to ascertain the prognostic effect of the PNI and the oxygen therapy requirement as predictors of hospital length of stay in patients with moderate to severe coronavirus disease 2019 (COVID-19). Methods: This is a post-hoc analysis in hospitalized patients with moderate to severe COVID-19. The participants were categorized: (1) non-oxygen therapy (moderate COVID-19 not requiring oxygen therapy); (2) nasal cannula therapy (severe COVID-19 requiring nasal cannula oxygen therapy); and (3) high-flow therapy (severe COVID-19 requiring high-flow oxygen therapy). PNI was calculated for each patient according to the following equation: serum albumin [g/dL] × 10 + total lymphocyte count [per mm3 ] × 0.005. The participants were categorized into malnutrition (PNI < 40), mild malnutrition (PNI 40–45), and non-malnutrition (PNI > 45). Results: According to PNI, malnutrition was more prevalent in the high-flow therapy group (94.9%; P < 0.001) with significantly lower PNI compared to both groups even after adjusting for the center and C-reactive protein. Patients in the high-flow therapy group [9 days (95% CI 7.2, 10.7), P < 0.001] and malnutrition status [7 days (95% CI 6.6, 7.4), P = 0.016] showed a significant longer hospital length of stay compared to their counterparts. The multivariable Cox proportional hazard models showed significant associations between both oxygen therapy requirement and PNI categories and hospital discharge. Conclusion: In addition to oxygen therapy requirement, low PNI was associated with longer hospital length of stay. Our findings suggest that PNI could be useful in the assessment of nutritional status related to the prognosis of patients with moderate to severe COVID-19pt_BR
dc.identifier.citationFERNANDES, Alan Lins; REIS, Bruna Zavarize; MUIRAI, Igor Hisashi; PEREIRA, Rosa Maria Rodrigues. Prognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analyses. Frontiers in Nutrition, [S.l.], v. 9, p. 1-9, 5 abr. 2022. DOI: 10.3389/fnut.2022.802562. Disponível em: https://www.frontiersin.org/articles/10.3389/fnut.2022.802562/full. Acesso em: 16 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3389/fnut.2022.802562
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57730
dc.languageenpt_BR
dc.publisherFrontiers in Nutritionpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectSARS-CoV-2 infectionpt_BR
dc.subjectCOVID-19pt_BR
dc.subjectMalnutritionpt_BR
dc.subjectPrognosispt_BR
dc.subjectNutritional statuspt_BR
dc.subjectAssessmentpt_BR
dc.subjectPrognostic nutritional indexpt_BR
dc.subjectPNIpt_BR
dc.titlePrognostic nutritional index and cxygen therapy requirement associated with longer hospital length of stay in patients with moderate to severe COVID-19: multicenter prospective cohort analysespt_BR
dc.typearticlept_BR

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