Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression

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dc.contributor.authorSantiago, Giuliana Travassos Pires
dc.contributor.authorGalvão, Ana Cecília de Menezes
dc.contributor.authorAlmeida, Raíssa Nóbrega de
dc.contributor.authorMota-Rolim, Sergio Arthuro
dc.contributor.authorPalhano-Fontes, Fernanda
dc.contributor.authorMaia-de-Oliveira, João Paulo
dc.contributor.authorAraújo, Dráulio Barros de
dc.contributor.authorLobão-Soares, Bruno
dc.contributor.authorGalvão-Coelho, Nicole Leite
dc.date.accessioned2020-05-12T18:07:12Z
dc.date.available2020-05-12T18:07:12Z
dc.date.issued2020-04-28
dc.description.resumoSleep disturbance is a symptom consistently found in major depression and is associated with a longer course of illness, reduced response to treatment, increased risk of relapse and recurrence. Chronic insomnia has been associated with changes in cortisol and serum brain-derived neurotrophic factor (BDNF) levels, which in turn are also changed in major depression. Here, we evaluated the relationship between sleep quality, salivary cortisol awakening response (CAR), and serum BDNF levels in patients with sleep disturbance and treatment-resistant major depression (n = 18), and in a control group of healthy subjects with good (n = 21) and poor (n = 18) sleep quality. We observed that the patients had the lowest CAR and sleep duration of all three groups and a higher latency to sleep than the healthy volunteers with a good sleep profile. Besides, low CAR was correlated with more severe depressive symptoms and worse sleep quality. There was no difference in serum BDNF levels between groups with distinct sleep quality. Taken together, our results showed a relationship between changes in CAR and in sleep quality in patients with treatment-resistant depression, which were correlated with the severity of disease, suggesting that cortisol could be a physiological link between sleep disturbance and major depression.pt_BR
dc.identifier.citationSANTIAGO, G. T. P. et al. Changes in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depression. Front. Behav. Neurosci., [S. l.], v. 14, p.44, abr. 2020.pt_BR
dc.identifier.doi10.3389/fnbeh.2020.00044
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/28961
dc.languageenpt_BR
dc.subjectPittsburgh sleep quality indexpt_BR
dc.subjectbrain-derived neurotrophic factorpt_BR
dc.subjectsalivary cortisol awakening responsept_BR
dc.subjectsleep disturbancept_BR
dc.subjecttreatment-resistant depressionpt_BR
dc.titleChanges in cortisol but not in brain-derived neurotrophic factor modulate the association between sleep disturbances and major depressionpt_BR
dc.typearticlept_BR

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