Brain derived neutrophic factor, a link of aerobic metabolism to neuroplasticity

dc.contributor.authorAssis, G. G.
dc.contributor.authorSousa, Maria Bernardete Cordeiro de
dc.contributor.authorKozacz, A.
dc.contributor.authorMurawska-Cialowicz, E.
dc.date.accessioned2019-01-08T18:42:45Z
dc.date.available2019-01-08T18:42:45Z
dc.date.issued2018-10
dc.description.resumoCurrently, literature has accumulated great knowledge over the effect of exercise on the neurotrophin named brain derived neurotrophic factor (BDNF) and its role in neuronal plasticity. However, there is no enough discussion about how the exercise is related to enrichment of BDNF in specific metabolic properties. This review provides the current evidences regarding aerobic metabolism relation to BDNF concentrations in healthy individuals. A PICOS strategy was applied considering the mesh terms for: P - healthy subjects; I - physical exercise; C - aerobic metabolism demands; O - BDNF concentrations; S - before and after aerobic exercise; on PubMed, Scopus and Medline databases. Studies presenting at least one session the exercise with reports of BDNF analysis before and after were included. Reviews, letters, case-reports, articles not written in English, non- published or involving non-healthy populations were excluded. Compiling results, it was possible to observe a close interaction between different aerobic energy demands from the exercise models and the responses of BDNF, suggesting thus that increases in BDNF concentrations are associated to the amount of aerobic energy required by exercise in a dose-dependent manner. Moreover, the dynamics of BDNF synthesis and reuptake resemble the functioning of the metabolic systems of aerobic energy generation, with which they share a co-transcriptional factor dependence.pt_BR
dc.identifier.citationASSIS, G. G. et al. Brain derived neutrophic factor, a link of aerobic metabolism to neuroplasticity. J Physiol Pharmacol., v. 69, n. 3, p. 351-358, jun. 2018. doi: 10.26402/jpp.2018.3.12.pt_BR
dc.identifier.doi10.26402/jpp.2018.3.12
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/26432
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectBrain derived neurotrophic factorpt_BR
dc.subjectaerobic metabolismpt_BR
dc.subjectaerobic exercisept_BR
dc.subjectneuroplasticitypt_BR
dc.subjectprolonged exercisept_BR
dc.subjectproliferator-activated receptor gamma co-activator 1-alphapt_BR
dc.titleBrain derived neutrophic factor, a link of aerobic metabolism to neuroplasticitypt_BR
dc.typearticlept_BR

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