Terpenes nanoencapsulation in polylactic acid nanoparticles: potential active pharmaceutical ingredients and their applications

Página do item simplificado Estatísticas
dc.contributor.advisorSilva Júnior, Arnóbio Antônio da
dc.contributor.advisor-co1Souza, Aleph Matthews da Silva
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/9571864533462140pt_BR
dc.contributor.advisorLatteshttp://lattes.cnpq.br/2593509584288129pt_BR
dc.contributor.authorSantos, Reno Costa dos
dc.contributor.referees1Almeida, Addison Ribeiro de
dc.contributor.referees1Latteshttp://lattes.cnpq.br/8978902014231167pt_BR
dc.contributor.referees2Medeiros, Thayse Silva
dc.contributor.referees2Latteshttp://lattes.cnpq.br/1987367321820890pt_BR
dc.date.accessioned2024-08-13T14:10:35Z
dc.date.available2024-08-13T14:10:35Z
dc.date.issued2024-06-19
dc.description.resumoThe terpenes phytol (PHY), caryophyllene (BCR) and myrcene (MYR) exhibit biological activities and literature suggests that they could be used as active pharmaceutical ingredients (APIs). However, they present some limitations, such as low water solubility and bioavailability, high volatility, and hydrophobicity. In this sense, loading these terpenes in polymeric nanoparticles (NPs) has the potential to overcome these issues, and become useful nanomedicines to treat some diseases. Therefore, the objective of this study was to evaluate NP systems based on polylactic acid (PLA) previously developed to incorporate PHY, BCR, and MYR. The terpenes-loaded NPs were prepared by the nanoprecipitation method with different terpenes concentration and were characterized according to the dynamic light scattering (DLS) method, wherein the parameters hydrodynamic diameter (size), polydispersity index (PdI), and Zeta potential were studied. Furthermore, the NPs were characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR), and preliminary biocompatibility. The terpene-loading NP was considered stable during the studied time and exhibited a mean diameter between 150-250 nm, monodisperse, and a negative Zeta potential in the range of -20 to -30 mV. Additionally, SEM and FTIR were useful to characterize the terpene-loading NP. Finally, the terpene content loaded in the nanoparticles was studied by gas chromatography and showed 1.13 and 0.28 DL(%), to PHY and BCR, respectively. In addition, a significant reduction in hemolytic profile was also observed when the terpene-loading NP was compared to the terpene solution, suggesting better biocompatibility in the NP.pt_BR
dc.identifier.citationSANTOS, Reno Costa dos. Terpenes nanoencapsulation in polylactic acid nanoparticles: potential active pharmaceutical ingredients and their applications. Orientador: Arnóbio Antônio da Silva júnior. 2024. 24 f. Trabalho de Conclusão de Curso (Graduação em Farmácia), Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2024.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59162
dc.languageenpt_BR
dc.publisherUniversidade Federal do Rio Grande do Nortept_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFRNpt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectFarmacologiapt_BR
dc.subjectTerpenospt_BR
dc.subjectFitolpt_BR
dc.subjectNanopartículas poliméricaspt_BR
dc.subjectCariofilenopt_BR
dc.subjectMircenopt_BR
dc.subjectTerpenespt_BR
dc.subjectPhytolpt_BR
dc.subjectMyrcenept_BR
dc.subjectCaryophyllenept_BR
dc.subjectPolymeric nanoparticlespt_BR
dc.subjectPolylatic acid - PLApt_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDEpt_BR
dc.titleTerpenes nanoencapsulation in polylactic acid nanoparticles: potential active pharmaceutical ingredients and their applicationspt_BR
dc.title.alternativeTerpenes nanoencapsulation in polylactic acid nanoparticles: potential active pharmaceutical ingredients and their applicationspt_BR
dc.typebachelorThesispt_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
Terpenesnanoencapsulation_Santos_2024.pdf
Tamanho:
873.69 KB
Formato:
Adobe Portable Document Format
Nenhuma Miniatura disponível
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.45 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

CCS - TCC - Farmácia
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM