Uso da terapia fotodinâmica antimicrobiana no tratamento de candidose oral: ensaio clínico, controlado e randomizado

Abstract

INTRODUCTION: Oral erythematous candidiasis is a common fungal infection in users of complete dentures. patients often exhibit resistance to conventional treatment. New therapies are emerging as alternatives for its treatment, such as antimicrobial photodynamic therapy(aPDT). AIM:Analysis in patients diagnosed with oral erythematous candidiasis, who were divided into a control group, treated with oral nystatin suspension, and an intervention group, treated with aPDT sections. METHODS: The present study consists of a clinical, controlled and randomized trial conducted by means of a clinical and microbiological analysis in patients diagnosed with oral erythematous candidiasis, who were divided into a control group, treated with oral nystatin suspension, and an intervention group, treated with aPDT sections. Patients were reassessed as to the effectiveness of treatment through the application of a clinical index, in addition to microbiological analysis,in pre-established periods (7,14,21 and 30 days).RESULTS:Of 41 patients analyzed in our research, 32 (78%) were successful in their treatment,4 (9,8%) were unsuccessful, and 5 (12,2%) gave up treatment. Patients were also analyzed for the degree of the lesion, and it was observed that those of the severe type had more difficulty in presenting remission, while the lesions mild and moderate, all showed regression. The case group exhibited similar results to the control group, however, there were no statistically significant differences between the groups, as far as treatment success was concerned, in microbiological analyzes, in which the predominance of Candida albicans, among the species of Candida ssp. and Staphylococcus ssp. in dental prostheses. CONCLUSIONS: aPDT is a promising treatment alternative, as it presents satisfactory results, does not cause changes to oral tissues and its use does not lead to the development of resistance to treatment, so further studies with larger samples are needed to verify its effectiveness.