Azilsartan Increases Levels of IL-10, Down-Regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and Up- Regulates OPG in an Experimental Periodontitis Model

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dc.contributor.authorAraújo, Aurigena Antunes de
dc.contributor.authorVarela, Hugo
dc.contributor.authorBrito, Gerly Anne de Castro
dc.contributor.authorMedeiros, Caroline Addison Carvalho Xavier de
dc.contributor.authorAraújo, Lorena de Souza
dc.contributor.authorNascimento, José Heriberto Oliveira do
dc.contributor.authorAraújo Júnior, Raimundo Fernandes de
dc.date.accessioned2018-06-16T11:49:09Z
dc.date.available2018-06-16T11:49:09Z
dc.date.issued2014-05-12
dc.description.resumoAims The aim of this study was to evaluate the effects of azilsartan (AZT) on bone loss, inflammation, and the expression of matrix metallo proteinases (MMPs), receptor activator of nuclear factor κB ligand (RANKL), receptor activator of nuclear factor κB (RANK), osteoprotegerin (OPG), cyclooxygenase-2 (COX-2), and cathepsin K in periodontal tissue in a rat model of ligature-induced periodontitis. Materials and Methods Male Wistar albino rats were randomly divided into 5 groups of 10 rats each: (1) nonligated, water; (2) ligated, water; (3) ligated, 1 mg/kg AZT; (4) ligated, 5 mg/kg AZT; and (5) ligated, 10 mg/kg AZT. All groups were treated with saline or AZT for 10 days. Periodontal tissues were analyzed by histopathology and immunohistochemical detection of MMP-2, MMP-9, COX-2, RANKL, RANK, OPG, and cathepsin K. Levels of IL-1β, IL-10, TNF-α, myeloperoxidase (MPO), and glutathione (GSH) were determined by ELISA. Results Treatment with 5 mg/kg AZT resulted in reduced MPO (p<0.05) and IL-1β (p<0.05), increased levels of IL-10 (p<0.05), and reduced expression of MMP-2, MMP-9, COX-2, RANK, RANKL, cathepsin K, and increased expression of OPG. Conclusions These findings reveal that AZT increases anti-inflammatory cytokines and GSH and decreases bone loss in ligature-induced periodontitis in rats.pt_BR
dc.identifier.citationARAÚJO, Aurigena Antunes de et al. Azilsartan Increases Levels of IL-10, Down-Regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and Up-Regulates OPG in an Experimental Periodontitis Model. Plos One, v. 9, p. 01-08, 2014. Disponível em: <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0096750>. Acesso em: 19 mar. 2018.pt_BR
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0096750
dc.identifier.issn1932-6203
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25421
dc.languageengpt_BR
dc.publisherFaculté de Médecine de Nantes, Francept_BR
dc.rightsAcesso Abertopt_BR
dc.subjectazilsartanpt_BR
dc.titleAzilsartan Increases Levels of IL-10, Down-Regulates MMP-2, MMP-9, RANKL/RANK, Cathepsin K and Up- Regulates OPG in an Experimental Periodontitis Modelpt_BR
dc.typearticlept_BR

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