Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features

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dc.contributor.authorCorrea, Romualdo da Silva
dc.contributor.authorMarques, Diego
dc.contributor.authorCosta, Layse Raynara Ferreira
dc.contributor.authorCosta, Lorenna Larissa Ferreira
dc.contributor.authorBorges, Aline Maciel Pinheiro
dc.contributor.authorIto, Fernanda Ribeiro
dc.contributor.authorRamos, Carlos Cesar de Oliveira
dc.contributor.authorBortolin, Raul Hernandes
dc.contributor.authorLuchessi, André Ducati
dc.contributor.authorSantos, Ândrea Ribeiro dos
dc.contributor.authorSantos, Sidney
dc.contributor.authorSilbiger, Vivian Nogueira
dc.date.accessioned2023-07-06T18:19:33Z
dc.date.available2023-07-06T18:19:33Z
dc.date.issued2017-10-07
dc.description.resumoAIM To investigate the association between 16 insertion-deletions (INDEL) polymorphisms, colorectal cancer (CRC) risk and clinical features in an admixed population. Methodos: One hundred and forty patients with CRC and 140 cancer-free subjects were examined. Genomic DNA was extracted from peripheral blood samples. Polymorphisms and genomic ancestry distribution were assayed by Multiplex-PCR reaction, separated by capillary electrophoresis on the ABI 3130 Genetic Analyzer instrument and analyzed on GeneMapper ID v3.2. Clinicopathological data were obtained by consulting the patients’ clinical charts, intra-operative documentation, and pathology scoring. Rerults: Logistic regression analysis showed that polymorphism variations in IL4 gene was associated with increased CRC risk, while TYMS and UCP2 genes were associated with decreased risk. Reference to anatomical localization of tumor Del allele of NFKB1 and CASP8 were associated with more colon related incidents than rectosigmoid. In relation to the INDEL association with tumor node metastasis (TNM) stage risk, the Ins alleles of ACE, HLAG and TP53 (6 bp INDEL) were associated with higher TNM stage. Furthermore, regarding INDEL association with relapse risk, the Ins alleles of ACE, HLAG, and UGT1A1 were associated with early relapse risk, as well as the Del allele of TYMS. Regarding INDEL association with death risk before 10 years, the Ins allele of SGSM3 and UGT1A1 were associated with death risk. Conclusion: The INDEL variations in ACE, UCP2, TYMS, IL4, NFKB1, CASP8, TP53, HLAG, UGT1A1, and SGSM3 were associated with CRC risk and clinical features in an admixed population. These data suggest that this cancer panel might be useful as a complementary tool for better clinical management, and more studies need to be conducted to confirm these findings.pt_BR
dc.identifier.citationCORREA, Romualdo da Silva; MARQUES, Diego; FERREIRA-COSTA, Layse Raynara; FERREIRA-COSTA, Lorenna Larissa; BORGES, Aline Maciel Pinheiro; ITO, Fernanda Ribeiro; RAMOS, Carlos Cesar de Oliveira; BORTOLIN, Raul Hernandes; LUCHESSI, André Ducati; RIBEIRO-DOS-SANTOS, Ândrea. Association of insertion-deletions polymorphisms with colorectal cancer risk and clinical features. World Journal Of Gastroenterology, [S.L.], v. 23, n. 37, p. 6854-6867, 7 out. 2017. Baishideng Publishing Group Inc.. http://dx.doi.org/10.3748/wjg.v23.i37.6854. Disponível em: https://www.wjgnet.com/1007-9327/full/v23/i37/6854.htm. Acesso em: 05 jul. 2023.pt_BR
dc.identifier.doihttps://dx.doi.org/10.3748/wjg.v23.i37.6854
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/53102
dc.languageenpt_BR
dc.publisherWorld Journal Of Gastroenterologypt_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subjectcolorectal cancerpt_BR
dc.subjectins-del polymorphismpt_BR
dc.subjectadmixed populationpt_BR
dc.subjectpotential biomarkerpt_BR
dc.subjectdiagnosticpt_BR
dc.subjectrisk stratificationpt_BR
dc.subjectprognosticpt_BR
dc.subjectclinical featurespt_BR
dc.titleAssociation of insertion-deletions polymorphisms with colorectal cancer risk and clinical featurespt_BR
dc.typearticlept_BR

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