Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor

dc.contributor.authorMikulovic, Sanja
dc.contributor.authorRestrepo, Carlos Ernesto
dc.contributor.authorSiwani, Samer
dc.contributor.authorBauer, Pavol
dc.contributor.authorPupe, Stefano
dc.contributor.authorTort, Adriano Bretanha Lopes
dc.contributor.authorKullander, Klas
dc.contributor.authorLeão, Richardson Naves
dc.date.accessioned2018-09-13T14:01:19Z
dc.date.available2018-09-13T14:01:19Z
dc.date.issued2018-09
dc.description.resumoDorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions.pt_BR
dc.identifier.doi10.1038/s41467-018-05907-w
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25830
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectVentral hippocampalpt_BR
dc.subjectOLMpt_BR
dc.subjecttheta oscillationspt_BR
dc.titleVentral hippocampal OLM cells control type 2 theta oscillations and response to predator odorpt_BR
dc.typearticlept_BR

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