Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
dc.contributor.author | Mikulovic, Sanja | |
dc.contributor.author | Restrepo, Carlos Ernesto | |
dc.contributor.author | Siwani, Samer | |
dc.contributor.author | Bauer, Pavol | |
dc.contributor.author | Pupe, Stefano | |
dc.contributor.author | Tort, Adriano Bretanha Lopes | |
dc.contributor.author | Kullander, Klas | |
dc.contributor.author | Leão, Richardson Naves | |
dc.date.accessioned | 2018-09-13T14:01:19Z | |
dc.date.available | 2018-09-13T14:01:19Z | |
dc.date.issued | 2018-09 | |
dc.description.resumo | Dorsal and ventral hippocampus regions exert cognition and emotion-related functions, respectively. Since both regions display rhythmic activity, specific neural oscillatory pacemakers may underlie their functional dichotomy. Type 1 theta oscillations are independent of cholinergic transmission and are observed in the dorsal hippocampus during movement and exploration. In contrast, type 2 theta depends on acetylcholine and appears when animals are exposed to emotionally laden contexts such as a predator presence. Despite its involvement in emotions, type 2 theta has not been associated with the ventral hippocampus. Here, we show that optogenetic activation of oriens-lacunosum moleculare (OLM) interneurons in the ventral hippocampus drives type 2 theta. Moreover, we found that type 2 theta generation is associated with increased risk-taking behavior in response to predator odor. These results demonstrate that two theta oscillations subtypes originate in the two hippocampal regions that predominantly underlie either cognitive or emotion-related functions. | pt_BR |
dc.identifier.doi | 10.1038/s41467-018-05907-w | |
dc.identifier.uri | https://repositorio.ufrn.br/jspui/handle/123456789/25830 | |
dc.language | eng | pt_BR |
dc.rights | Acesso Aberto | pt_BR |
dc.subject | Ventral hippocampal | pt_BR |
dc.subject | OLM | pt_BR |
dc.subject | theta oscillations | pt_BR |
dc.title | Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor | pt_BR |
dc.type | article | pt_BR |
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