Efeito do ácido hialurônico adjunto à raspagem e alisamento corono-radicular em pacientes com periodontite: uma revisão integrativa da literatura

Abstract

Objective: To evaluate the effect of adjunctive hyaluronic acid (HA) application in combination with scaling and root planing (SRP) in the treatment of patients with periodontitis. Methodology: An integrative literature review was conducted with 15 clinical studies analyzing the impact of HA on periodontal clinical parameters such as probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). The data sources included PubMed, Scopus, and BVS databases, with inclusion criteria focused on clinical trials that used HA as an adjunct to periodontal treatment. Data collection encompassed different concentrations, forms of application, and follow-up periods (ranging from 4 weeks to 12 months). Results: The analysis indicated that HA use led to statistically significant improvements in PD, CAL, and BOP compared to the control group. Specific studies reported more pronounced reductions in PD (1 mm on average) and gains in CAL (up to 3 mm in some cases) in the HA-treated groups. HA also demonstrated anti-inflammatory and regenerative properties, with positive impacts on reducing inflammatory markers and promoting initial bone regeneration. Conclusion: The application of hyaluronic acid as an adjunctive therapy to SRP proved effective in improving clinical parameters and reducing inflammation in patients with periodontitis, particularly in moderate to deep pockets. However, the literature still lacks consensus on optimal concentrations, application protocols, and long-term effects.