Computational models of memory consolidation and long-term synaptic plasticity during sleep

Rennó-Costa, César; Silva, Ana Cláudia Costa da; Blanco, Wilfredo; Ribeiro, Sidarta Tollendal Gomes

Computational models of memory consolidation and long-term synaptic plasticity during sleep

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dc.contributor.author	Rennó-Costa, César
dc.contributor.author	Silva, Ana Cláudia Costa da
dc.contributor.author	Blanco, Wilfredo
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes
dc.date.accessioned	2018-10-23T14:00:17Z
dc.date.available	2018-10-23T14:00:17Z
dc.date.issued	2018-10-11
dc.description.resumo	The brain stores memories by persistently changing the connectivity between neurons. Sleep is known to be critical for these changes to endure. Research on the neurobiology of sleep and the mechanisms of long-term synaptic plasticity has provided data in support of various theories of how brain activity during sleep affects long-term synaptic plasticity. The experimental findings – and therefore the theories – are apparently quite contradictory, with some evidence pointing to a role of sleep in the forgetting of irrelevant memories, whereas other results indicate that sleep supports the reinforcement of the most valuable recollections. A unified theoretical framework is in need. Computational modeling and simulation provide grounds for the quantitative testing and comparison of theoretical predictions and observed data, and might serve as a strategy to organize the rather complicated and diverse pool of data and methodologies used in sleep research. This review article outlines the emerging progress in the computational modeling and simulation of the main theories on the role of sleep in memory consolidation	pt_BR
dc.identifier.doi	doi.org/10.1016/j.nlm.2018.10.003
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/26048
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Homeostasis	pt_BR
dc.subject	Sequential	pt_BR
dc.subject	Replay	pt_BR
dc.subject	Active consolidation	pt_BR
dc.subject	Embossing	pt_BR
dc.subject	Down-scaling	pt_BR
dc.subject	Up-scalin	pt_BR
dc.subject	Simulation	pt_BR
dc.subject	LTP	pt_BR
dc.subject	LTD	pt_BR
dc.title	Computational models of memory consolidation and long-term synaptic plasticity during sleep	pt_BR
dc.type	article	pt_BR