Safety of Abciximab injection during endovascular treatment of ruptured aneurysms

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dc.contributor.authorGentric, Jean-Christophe
dc.contributor.authorBrisson, Joelle
dc.contributor.authorBatista, André Lima
dc.contributor.authorGhostine, Jimmy
dc.contributor.authorRaymond, Jean
dc.contributor.authorRoy, Daniel
dc.contributor.authorWeill, Alain
dc.date.accessioned2023-05-17T19:37:10Z
dc.date.available2023-05-17T19:37:10Z
dc.date.issued2015-05
dc.description.resumoBackground and purpose: We aimed to determine the safety of intra-arterial Abciximab injection in the management of thromboembolic complications during endovascular treatment of ruptured cerebral aneurysms. Methods: In a monocentric consecutive series of endovascular treatment of 783 ruptured aneurysms, 42 (5.3%) patients received Abciximab after the aneurysm was secured. Bleeding complications were registered and dichotomized as follows: new intracranial hemorrhage and peripheral bleeding. For each patient, World Federation of Neurosurgery (WFNS) sub arachnoid hemorrhage (SAH) grade, shunting, and clinical outcomes in the post-operative period and at 3–6 months were recorded. Results: SAH WFNS grades were as follows: grade I n ¼ 14, grade II n ¼ 10, grade III n ¼ 11, grade IV n ¼ 4, grade V n ¼ 3. Ten patients had intracranial hematoma additionally to the SAH prior to embolization. Four patients (9.5%) presented more blood on the post-embolization CT but only one suffered a new clinically relevant intracranial hemorrhage. Two patients (4.8%) experienced significant peripheral bleeding but none were associated with long-term disabilities. Fourteen patients had a shunt installed less than 24 h prior to Abciximab injection and one less than 48 h later. At 3–6-month follow-up, 31 patients (74%) achieved a modified Rankin Scale score (mRS) of 2 or less, six patients (14%) had a mRS of 3–5, three were dead (7%), and two were lost at follow-up. Conclusion: When the aneurysm is secured, intra-arterial Abciximab injection is a low complication rate treatment modality for thromboembolic events during embolization of cerebral ruptured aneurysmpt_BR
dc.identifier.citationBATISTA, André Lima; et al. Safety of Abciximab injection during endovascular treatment of ruptured aneurysms. Interventional Neuroradiology, [S.L.], v. 21, n. 3, p. 332-336, 11 maio 2015. SAGE Publications. http://dx.doi.org/10.1177/1591019915582001.pt_BR
dc.identifier.doi10.1177/1591019915582001
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/52469
dc.languageenpt_BR
dc.publisherInterventional Neuroradiologypt_BR
dc.subjectsafetypt_BR
dc.subjectabciximabpt_BR
dc.subjectcerebral aneurysmpt_BR
dc.subjectsubarachnoid hemorrhagept_BR
dc.subjectaneurysm coilingpt_BR
dc.titleSafety of Abciximab injection during endovascular treatment of ruptured aneurysmspt_BR
dc.typearticlept_BR

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