Association of serum alpha-tocopherol and retinol with the extent of coronary lesions in coronary artery disease

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dc.contributor.authorRibeiro, Karla Danielly da Silva
dc.contributor.authorMiranda, Carolinne Thaísa de Oliveira Fernandes
dc.contributor.authorDuarte, Victor Hugo Rezende
dc.contributor.authorCruz, Marina Sampaio de Menezes
dc.contributor.authorDuarte, Mychelle Kytchia Rodrigues Nunes
dc.contributor.authorAraújo, Jéssica Nayara Góes de
dc.contributor.authorSantos, Ayda Maria Quirino Silva dos
dc.contributor.authorOliveira, Juliana Marinho de
dc.contributor.authorPaiva, Maria Sanali Moura Oliveira
dc.contributor.authorRezende, Adriana Augusto
dc.contributor.authorHirata, Mario Hiroyuki
dc.contributor.authorHirata, Rosario Dominguez Crespo
dc.contributor.authorLuchessi, André Ducati
dc.contributor.authorSilbiger, Vivian Nogueira
dc.contributor.authorIDhttps://orcid.org/0000-0001-7708-4271
dc.contributor.authorIDhttps://orcid.org/0000-0003-3073-5967
dc.contributor.authorIDhttps://orcid.org/0000-0002-9252-0278
dc.contributor.authorIDhttps://orcid.org/0000-0002-2251-5967
dc.contributor.authorIDhttps://orcid.org/0000-0002-3122-9073
dc.contributor.authorIDhttps://orcid.org/0000-0002-2276-690X
dc.contributor.authorIDhttps://orcid.org/0000-0003-2452-4047
dc.contributor.authorIDhttps://orcid.org/0000-0002-9521-7979
dc.contributor.authorIDhttps://orcid.org/0000-0002-2758-8102
dc.date.accessioned2025-06-27T15:37:51Z
dc.date.available2025-06-27T15:37:51Z
dc.date.issued2018-12-11
dc.description.resumoBackground and aims: Fat-soluble vitamins play an important role in the pathogenesis of cardiovascular disease and progression ofatherosclerosis. +is study aimed at investigating the relationship of the serum levels of alpha-tocopherol and retinol with theextent of coronary lesions in patients with coronary artery disease. Methods. Patients with coronary artery disease (n = 177) aged 30 – 74 years, who underwent their first coronary angiography, were enrolled. The extent of coronary lesions was assessed using th eFriesinger index (FI). Accordingly, patients were grouped as follows: FI = 0–4 (n = 90), FI = 5–9 (n = 50), and FI = 10–15 (n = 37).Serum levels of vitamins were determined via high-performance liquid chromatography and serum biochemical analysis. Results.Assessment of FI-based groups revealed that 50.8% patients had a coronary artery lesion to a low extent (FI 0–4). Individuals inthis group were younger and had lower glucose and serum alpha-tocopherol levels than the other groups (p < 0.05). Low levels of alpha-tocopherol were more frequent in the FI 0–4 group than that in the other groups (p = 0.03). No difference was observedbetween the mean serum retinol levels among the FI-based groups (n = 0.492), and the low frequency of retinol was consistentamong the FI groups (n = 0.348). Conclusions. The low level of alpha-tocopherol together with the presence of dyslipidemia isprobably associated with the initial events in atherosclerosis. Increased alpha-tocopherol levels in patients with more extensivecoronary artery lesions may have resulted from altered vitamin E metabolism with increased oxidative stress.
dc.identifier.citationFERNANDES, Cláudia Teresa Oliveira; CRUZ, Márcio; DUARTE, Valéria; DUARTE, Mariana Kelly Ribeiro Nascimento; ARAÚJO, José Newton Gomes; SANTOS, Ana; OLIVEIRA, João; PAIVA, Mariana; REZENDE, André; HIRATA, Maria Helena; HIRATA, Ricardo de Carvalho; RIBEIRO, Karla Danielly; LUCHESSI, André D. A.; SILBIGER, Valéria Nunes. Association of serum alpha-tocopherol and retinol with the extent of coronary lesions in coronary artery disease. Journal of Nutrition and Metabolism, v. 2018, DOI:http://dx.doi.org/10.1155/2018/6104169. p. 1-6, 2018. Disponível em: https://onlinelibrary.wiley.com/doi/10.1155/2018/6104169. Acesso em: 07 out. 2024.
dc.identifier.otherhttps://doi.org/10.1155/2018/6104169
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/64054
dc.language.isoen_US
dc.publisherJournal of Nutrition and Metabolism
dc.rightsAttribution 3.0 Brazilen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/
dc.subjectAlpha-Tocopherol
dc.subjectCoronary Artery Disease
dc.subjectCoronary artery lesions
dc.titleAssociation of serum alpha-tocopherol and retinol with the extent of coronary lesions in coronary artery disease
dc.typearticle

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