Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus

Rossato, Janine I.; Radiske, Andressa; Kohler, Cristiano A.; Gonzalez, Carolina; Bevilaqua, Lia Rejane Müller; Medina, Jorge H.; Cammarota, Martín Pablo

Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus

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dc.contributor.author	Rossato, Janine I.
dc.contributor.author	Radiske, Andressa
dc.contributor.author	Kohler, Cristiano A.
dc.contributor.author	Gonzalez, Carolina
dc.contributor.author	Bevilaqua, Lia Rejane Müller
dc.contributor.author	Medina, Jorge H.
dc.contributor.author	Cammarota, Martín Pablo
dc.date.accessioned	2018-11-16T17:25:10Z
dc.date.available	2018-11-16T17:25:10Z
dc.date.issued	2013-11
dc.description.resumo	The mesocorticolimbic dopaminergic system includes the ventral tegmental area (VTA) and its projections to the amygdala (AMY), the hippocampus (HIP) and the medial prefrontal cortex (mPFC), among others. Object recognition (OR) long-term memory (LTM) processing requires dopaminergic activity but, although some of the brain regions mentioned above are necessary for OR LTM consolidation, their possible dopamine-mediated interplay remains to be analyzed. Using adult male Wistar rats, we found that posttraining microinjection of the dopamine D1/D5 receptor antagonist SCH23390 in mPFC or AMY, but not in HIP, impaired OR LTM. The dopamine D2 receptor agonist quinpirole had no effect on retention. VTA inactivation also hindered OR LTM, and even though this effect was unaffected by co-infusion of the dopamine D1/D5 receptor agonist SKF38393 in HIP, mPFC or AMY alone, it was reversed by simultaneous activation of D1/D5 receptors in the last two regions. Our results demonstrate that the mesocorticolimbic dopaminergic system is indeed essential for OR LTM consolidation and suggest that the role played by some of its components during this process is much more complex than previously thought.	pt_BR
dc.identifier.citation	ROSSATO, J. I. et al. Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus. Neurobiology of Learning and Memory, v. 106, p. 66-70, nov./2013.	pt_BR
dc.identifier.doi	https://doi.org/10.1016/j.nlm.2013.07.012
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/26112
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Amygdala	pt_BR
dc.subject	Dopamine	pt_BR
dc.subject	Hippocampus	pt_BR
dc.subject	Medial prefrontal cortex	pt_BR
dc.subject	Object recognition memory	pt_BR
dc.subject	Ventral tegmental area	pt_BR
dc.title	Consolidation of object recognition memory requires simultaneous activation of dopamine D1/D5 receptors in the amygdala and medial prefrontal cortex but not in the hippocampus	pt_BR
dc.type	article	pt_BR