Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats

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dc.contributor.authorBrito, Naira J.N.
dc.contributor.authorLópez, Jorge A.
dc.contributor.authorNascimento, Maria Aparecida do
dc.contributor.authorMacêdo, José B.M.
dc.contributor.authorSilva, Gabriel Araujo
dc.contributor.authorOliveira, Cláudia N.
dc.contributor.authorRezende, Adriana Augusto de
dc.contributor.authorBrandão-Neto, José
dc.contributor.authorSchwarz, Aline
dc.contributor.authorAlmeida, Maria das Graças
dc.date.accessioned2021-09-30T18:45:50Z
dc.date.available2021-09-30T18:45:50Z
dc.date.issued2012-12
dc.description.resumoThe present study aimed to determine whether the leaves of Turnera ulmifolia Linn. var. elegans extract exert significant antioxidant activity. The antioxidant activity of its hydroethanolic extract (HEETU) was evaluated by assessing (a) its radical scavenging ability in vitro, and (b) its in vivo effect on lipid peroxidation and antioxidant enzyme activities. The in vitro antioxidant assay (DPPH) clearly supported HEETU free radical scavenging potential. Moreover, glutathione content and antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase and catalase) were significantly enhanced in CCl4- treated rats due to oral HEETU-treatment (500 mg/kg b.w.) over 7 and 21 days. In addition, an improvement was observed in lipid peroxidation and serum biochemical parameters (aspartate aminotransferase and alanine aminotransferase), indicating a protective effect against CCl4-induced liver injuries, confirmed by histopathological studies. The HEETU effect was comparable to the standard drug Legalon (50 mg/kg b.w.) under the same experimental condition. Quantitative analysis of the HPLC extract revealed the presence of flavonoids, wich mediate the effects of antioxidant and oxidative stress. In conclusion, extract components exhibit antioxidant and hepatoprotective activities in vitro and in vivo.pt_BR
dc.identifier.citationBRITO, Naira J.N.; LÓPEZ, Jorge A.; NASCIMENTO, Maria Aparecida do; MACêDO, José B.M.; SILVA, Gabriel Araujo; OLIVEIRA, Cláudia N.; REZENDE, Adriana Augusto de; BRANDÃO-NETO, José; SCHWARZ, Aline; ALMEIDA, Maria das Graças. Antioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in rats. Food And Chemical Toxicology, [S.L.], v. 50, n. 12, p. 4340-4347, dez. 2012. Elsevier BV. http://dx.doi.org/10.1016/j.fct.2012.08.003. Disponível em: https://www.sciencedirect.com/science/article/pii/S027869151200556X?via%3Dihub. Acesso em: 30 set. 2021.pt_BR
dc.identifier.issn0278-6915
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/40852
dc.languagept_BRpt_BR
dc.publisherElsevierpt_BR
dc.subjectTurnera ulmifolia Linn. var. eleganspt_BR
dc.subjectHepatic damagept_BR
dc.subjectAntioxidantspt_BR
dc.titleAntioxidant activity and protective effect of Turnera ulmifolia Linn. var. elegans against carbon tetrachloride-induced oxidative damage in ratspt_BR
dc.typearticlept_BR

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