Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction

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dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.contributor.authorCarvalho, Fabiana Maria Coimbra de
dc.contributor.authorLima, Vanessa Cristina Oliveira de
dc.contributor.authorCosta, Izael Souza
dc.contributor.authorLuz, Anna Beatriz Santana
dc.contributor.authorLadd, Fernando Vagner Lobo
dc.contributor.authorSerquiz, Alexandre Coelho
dc.contributor.authorBortolin, Raul Hernandes
dc.contributor.authorSilbiger, Vivian Nogueira
dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorSantos, Elizeu Antunes dos
dc.contributor.authorIDhttps://orcid.org/0000-0002-6460-911Xpt_BR
dc.date.accessioned2023-09-01T21:27:45Z
dc.date.available2023-09-01T21:27:45Z
dc.date.issued2019
dc.description.resumoThe increasing prevalence of obesity and, consequently, chronic inflammation and its complications has increased the search for new treatment methods. The effect of the purified tamarind seed trypsin inhibitor (TTIp) on metabolic alterations in Wistar rats with obesity and dyslipidemia was evaluated. Three groups of animals with obesity and dyslipidemia were formed, consuming a high glycemic index and glycemic load (HGLI) diet, for 10 days: Obese/HGLI diet; Obese/standard diet; Obese/HGLI diet + TTIp (730 µg/kg); and one eutrophic group of animals was fed a standard diet. Rats were evaluated daily for food intake and weight gain. On the 11th day, animals were anesthetized and sacrificed for blood and visceral adipose tissue collection. TTIp treated animals presented significantly lower food intake than the untreated group (p = 0.0065), TG (76.20 ± 18.73 mg/dL) and VLDL-C (15.24 ± 3.75 mg/dL). Plasma concentrations and TNF-α mRNA expression in visceral adipose tissue also decreased in obese animals treated with TTIp (p < 0.05 and p = 0.025, respectively) with a negative immunostaining. We conclude that TTIp presented anti-TNF-α activity and an improved lipid profile of Wistar rats with dyslipidemia and obesity induced by a high glycemic index and load diet regardless of PPAR-γ induction.pt_BR
dc.identifier.citationCARVALHO, Fabiana Maria Coimbra de. Anti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ induction. Nutrients, v. 11, n. 3, p. 512, 2019. Disponível em: https://www.mdpi.com/2072-6643/11/3/512. Acesso em: 5 jul. 2023pt_BR
dc.identifier.doi10.3390/nu11030512
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54665
dc.languageenpt_BR
dc.publisherNutrientspt_BR
dc.subjectInflammationpt_BR
dc.subjecttamarindus indica L.pt_BR
dc.subjecttriglyceridespt_BR
dc.subjectVLDLpt_BR
dc.titleAnti-TNF-α agent tamarind kunitz trypsin inhibitor improves lipid profile of Wistar rats presenting dyslipidemia and diet-induced obesity regardless of PPAR-γ inductionpt_BR
dc.typearticlept_BR

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