Pro-inflammatory diet Is correlated with high veillonella rogosae, gut inflammation and clinical relapse of inflammatory bowel disease

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dc.contributor.authorLyra, Clelia de Oliveira
dc.contributor.authorRocha, Ilanna Marques Gomes da
dc.contributor.authorTorrinhas, Raquel
dc.contributor.authorFonseca, Danielle
dc.contributor.authorNeri, Julianna Lys de Sousa Alves
dc.contributor.authorBalmant, Bianca Depieri
dc.contributor.authorCallado, Letícia
dc.contributor.authorCharlton, Karen
dc.contributor.authorQueiroz, Natalia
dc.date.accessioned2024-03-18T20:17:09Z
dc.date.available2024-03-18T20:17:09Z
dc.date.issued2023-09
dc.description.resumoInflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, and are associated with gut dysbiosis, inflammation, and gut permeability. In this study, we investigated whether the inflammatory potential of the diet is associated with the gut microbiota profile, inflammation, and permeability in forty patients with IBD in clinical remission. The dietary inflammatory index (DII) score was used to assess the inflammatory potential of the diet. The fecal microbiota profile was analyzed using 16SrRNA (V3–V4) gene sequencing, while fecal zonulin and calprotectin levels were measured with enzyme-linked immunosorbent assays. We found a positive correlation between the DII score and elevated calprotectin levels (Rho = 0.498; p = 0.001), but not with zonulin levels. Although α- and β-diversity did not significantly differ across DII quartiles, the most pro-inflammatory diet group exhibited a higher fecal abundance of Veillonella rogosae (p = 0.026). In addition, the abundance of some specific bacteria sequences showed an exponential behavior across DII quartiles and a correlation with calprotectin or zonulin levels (p ≤ 0.050). This included a positive correlation between sq702. Veillonella rogosae and fecal calprotectin levels (Rho = 0.419, p = 0.007). DII, calprotectin, and zonulin levels were identified as significant predictors of 6-month disease relapse (p ≤ 0.050). Our findings suggest a potential relationship of a pro-inflammatory diet intake with Veillonella rogosae and calprotectin levels in IBD patients in clinical remission, which may contribute to disease relapsept_BR
dc.identifier.citationROCHA, Ilanna Marques Gomes da; TORRINHAS, Raquel; FONSECA, Danielle; LYRA, Clelia de Oliveira; NERI, Julianna Lys de Sousa Alves; BALMANT, Bianca Depieri; CALLADO, Letícia; CHARLTON, Karen; QUEIROZ, Natalia; WAITZBERG, Dan Linetzky. Pro-inflammatory diet Is correlated with high veillonella rogosae, gut inflammation and clinical relapse of inflammatory bowel disease. Nutrients, [S.l.], v. 15, n. 19, p. 1-12, 26 set. 2023. DOI: 10.3390/nu15194148. Disponível em: https://www.mdpi.com/2072-6643/15/19/4148. Acesso em: 4 mar. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3390/nu15194148
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57879
dc.languageenpt_BR
dc.publisherNutrientspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectDietary inflammatory indexpt_BR
dc.subjectUlcerative colitispt_BR
dc.subjectCrohn’s diseasept_BR
dc.subjectGut microbiotapt_BR
dc.subjectInflammationpt_BR
dc.subjectCalprotectinpt_BR
dc.subjectZonulinpt_BR
dc.titlePro-inflammatory diet Is correlated with high veillonella rogosae, gut inflammation and clinical relapse of inflammatory bowel diseasept_BR
dc.typearticlept_BR

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