Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans

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dc.contributor.authorAzevêdo, Juliana Chris Silva
dc.contributor.authorBorges, Kátia Cristina
dc.contributor.authorGenovese, Maria Inês
dc.contributor.authorCorreia, Roberta Targino Pinto
dc.contributor.authorVattem, Dhiraj Anil
dc.date.accessioned2021-12-16T14:08:36Z
dc.date.available2021-12-16T14:08:36Z
dc.date.issued2015-07
dc.description.resumoThe effect of hot air dried camu-camu (Myrciaria dubia HBK McVaugh) residue on modulating redox response signaling was evaluated in transgenic Caenorhabditis elegans. Camu-camu residue was fractionated into low and high molecular weight fractions and used as treatments. Relative fold changes in gene expression in response to camu-camu treatments were quantified using fluorescence microscopy. Also, the neuroprotective effects of camu-camu residue in experimentally induced neurodegeneration were evaluated in C. elegans models for Alzheimer's disease (AD) and Parkinson's disease (PD). For AD, time to thermally induced Aβ1–42 aggregation mediated paralysis was evaluated in transgenic C. elegans (CL4176). For PD, MPP + induced neurodegeneration was quantified by loss in motility due to paralysis. Results suggest a significant upregulation expression of superoxide dismutase (SOD-3 and SOD-4) and catalases (CTL-1; CTL-2; CTL-3) in response to treatment with camu-camu residue, especially with the low molecular weight fraction. Furthermore, treatment with this fraction significantly extended the life span in C. elegans by 20% and delayed Aβ1–42 induced paralysis by 21%. Additionally, treatment with camu-camu residue also abrogated MPP + induced neurodegeneration for PD by 15–21%pt_BR
dc.identifier.citationAZEVEDO, J. C.S.; MEDEIROS, K. C. B.; GENOVESE, M. I.; CORREIA, R. T. P.; VATTEM, D. . Neuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. elegans. Food Research International, v. 73, p. 135-141, 2015. Disponível em: https://www.sciencedirect.com/science/article/pii/S0963996915000769?via%3Dihub. Acesso em: 11 nov. 2021. https://doi.org/10.1016/j.foodres.2015.02.015pt_BR
dc.identifier.doi10.1016/j.foodres.2015.02.015
dc.identifier.issn0963-9969
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45392
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCamu-camupt_BR
dc.subjectNeurodegenerationpt_BR
dc.subjectLife spanpt_BR
dc.subjectAlzheimer's diseasept_BR
dc.subjectParkinson's diseasept_BR
dc.titleNeuroprotective effects of dried camu-camu (Myrciaria dubia HBK McVaugh) residue in C. eleganspt_BR
dc.typearticlept_BR

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