Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus

Radiske, Andressa; Gonzalez, Maria Carolina; Conde-Ocaziones, Sergio; Feitosa, Anatildes; Köhler, Cristiano A.; Bevilaqua, Lia Rejane Müller; Cammarota, Martín Pablo

Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus

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dc.contributor.author	Radiske, Andressa
dc.contributor.author	Gonzalez, Maria Carolina
dc.contributor.author	Conde-Ocaziones, Sergio
dc.contributor.author	Feitosa, Anatildes
dc.contributor.author	Köhler, Cristiano A.
dc.contributor.author	Bevilaqua, Lia Rejane Müller
dc.contributor.author	Cammarota, Martín Pablo
dc.date.accessioned	2017-09-11T17:32:56Z
dc.date.issued	2017-09-08
dc.description.embargo	2018-03-10
dc.description.resumo	Reactivated memories can be modified during reconsolidation, making this process a potential therapeutic target for post-traumatic stress disorder (PTSD), a mental illness characterized by the recurring avoidance of situations that evoke trauma-related fears. However, avoidance memory reconsolidation depends on a set of still loosely defined boundary conditions, limiting the translational value of basic research. In particular, the involvement of the hippocampus in fear-motivated avoidance memory reconsolidation remains controversial. Combining behavioral and electrophysiological analyses in male Wistar rats, we found that previous learning of relevant non-aversive information is essential to elicit the participation of the hippocampus in avoidance memory reconsolidation, which is associated with an increase in theta and gamma oscillations power and cross-frequency coupling in dorsal CA1 during reactivation of the avoidance response. Our results indicate that the hippocampus is involved in memory reconsolidation only when reactivation results in contradictory representations regarding the consequences of avoidance, and suggest that robust nesting of hippocampal theta-gamma rhythms at the time of retrieval is a specific reconsolidation marker.	pt_BR
dc.identifier.doi	10.1523/JNEUROSCI.1372-17.2017
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23832
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	memory	pt_BR
dc.subject	learning	pt_BR
dc.subject	post-traumatic stress disorder	pt_BR
dc.subject	gamma oscillations	pt_BR
dc.subject	theta	pt_BR
dc.subject	cross-frequency coupling	pt_BR
dc.title	Prior learning of relevant non-aversive information is a boundary condition for avoidance memory reconsolidation in the rat hippocampus	pt_BR
dc.type	article	pt_BR