The elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in mice

dc.contributor.authorSoares, Bruno Lobão
dc.contributor.authorAsth, Laila
dc.contributor.authorAndré, Eunice
dc.contributor.authorSoares, Vanessa de Paula
dc.contributor.authorGavioli, Elaine Cristina
dc.date.accessioned2022-10-24T22:54:33Z
dc.date.available2022-10-24T22:54:33Z
dc.date.issued2012-04-10
dc.description.resumoThe elevated T-maze (ETM) is an apparatus derived from the elevated plus-maze test, which is used to evaluate anxiety. Because anxiety is a biasing factor in models of memory, this study proposed the ETM as a task for the simultaneous assessment of memory and anxiety in mice. The ETM consists of one enclosed and two open arms. The procedure is based on the avoidance of open spaces learned during training session, in which mice were exposed to the enclosed arm as many times as needed to stay 300 s. In the test session, memory is assessed by re-exposing the mouse to the enclosed arm and the latency to enter an open arm was recorded. The anxiolytic diazepam (DZP; 1 or 2 mg/kg) and the amnestic biperiden (BPR; 0.5, 1 or 3 mg/kg) were injected at three distinct times: pre-training, post-training, and pre-test. Pretraining administration of BPR 1 and DZP 2 increased the number of trials needed to reach the avoidance criterion, suggesting a passive avoidance learning impairment. However, BPR induced hyperlocomotion, which could bias the interpretation of any BPR-induced effects during the training session. Pre-training injection of BPR did not affect the spontaneous increase in the latency to enter an open arm between trials, while DZP reduced latencies in the first three trials suggesting anxiolysis. In the test session, pre-training injection of BPR 1 and DZP 2 reduced latencies to enter an open arm, indicating memory impairment. Post-training and pre-test injection of DZP or BPR did not affect memory. In conclusion, the proposed ETM task is practical for the detection of the anxiolytic and amnesic effects of drugs.pt_BR
dc.identifier.citationSOARES, Bruno Lobão et al. The elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in mice. Brain Research Bulletin, v. 87, p. 526-533, 2012. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0361923012000391?via%3Dihub>. Acesso em: 23 mar. 2018.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.brainresbull.2012.02.008
dc.identifier.issn0361-9230
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/49622
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectMemorypt_BR
dc.subjectAnxietypt_BR
dc.subjectAnimal modelpt_BR
dc.subjectMousept_BR
dc.titleThe elevated T-maze task as an animal model to simultaneously investigate the effects of drugs on long-term memory and anxiety in micept_BR
dc.typearticlept_BR

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