Anti-obesity therapeutic targets studied in silico and in vivo: a systematic review

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dc.contributor.authorMaia, Juliana Kelly da Silva
dc.contributor.authorMedeiros, Wendjilla Fortunato de
dc.contributor.authorGomes, Ana Francisca Teixeira
dc.contributor.authorAguiar, Ana Júlia Felipe Camelo
dc.contributor.authorQueiroz, Jaluza Luana Carvalho de
dc.contributor.authorBezerra, Ingrid Wilza Leal
dc.contributor.authorPiuvezam, Grasiela
dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.date.accessioned2024-08-08T21:37:45Z
dc.date.available2024-08-08T21:37:45Z
dc.date.issued2024-04
dc.description.resumoIn the age of information technology and the additional computational search tools and software available, this systematic review aimed to identify potential therapeutic targets for obesity, evaluated in silico and subsequently validated in vivo. The systematic review was initially guided by the research question “What therapeutic targets have been used in in silico analysis for the treatment of obesity?” and structured based on the acronym PECo (P, problem; E, exposure; Co, context). The systematic review protocol was formulated and registered in PROSPERO (CRD42022353808) in accordance with the Preferred Reporting Items Checklist for Systematic Review and Meta-Analysis Protocols (PRISMA-P), and the PRISMA was followed for the systematic review. The studies were selected according to the eligibility criteria, aligned with PECo, in the following databases: PubMed, ScienceDirect, Scopus, Web of Science, BVS, and EMBASE. The search strategy yielded 1142 articles, from which, based on the evaluation criteria, 12 were included in the systematic review. Only seven these articles allowed the identification of both in silico and in vivo reassessed therapeutic targets. Among these targets, five were exclusively experimental, one was exclusively theoretical, and one of the targets presented an experimental portion and a portion obtained by modeling. The predominant methodology used was molecular docking and the most studied target was Human Pancreatic Lipase (HPL) (n = 4). The lack of methodological details resulted in more than 50% of the papers being categorized with an “unclear risk of bias” across eight out of the eleven evaluated criteria. From the current systematic review, it seems evident that integrating in silico methodologies into studies of potential drug targets for the exploration of new therapeutic agents provides an important tool, given the ongoing challenges in controlling obesitypt_BR
dc.identifier.citationMEDEIROS, Wendjilla Fortunato de; GOMES, Ana Francisca Teixeira; AGUIAR, Ana Júlia Felipe Camelo et al. Anti-obesity therapeutic targets studied in silico and in vivo: a systematic review. International Journal of Molecular Sciences, [S.l.], v. 25, n. 9, p. 1-24, 25 abr. 2024. DOI: 10.3390/ijms25094699. Disponível em: https://www.mdpi.com/1422-0067/25/9/4699. Acesso em: 8 maio 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3390/ijms25094699
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59078
dc.languageenpt_BR
dc.publisherInternational Journal of Molecular Sciencespt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectComputer simulationpt_BR
dc.subjectMolecular dynamics simulationpt_BR
dc.subjectMolecular docking simulationpt_BR
dc.subjectPeptidespt_BR
dc.subjectMolecular conformationpt_BR
dc.subjectObesitypt_BR
dc.titleAnti-obesity therapeutic targets studied in silico and in vivo: a systematic reviewpt_BR
dc.typearticlept_BR

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