Anti-infl ammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract

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dc.contributor.authorAraújo, Aurigena Antunes de
dc.contributor.authorPorto, Cínthia R. C.
dc.contributor.authorSoares, Luiz A. L.
dc.contributor.authorSouza, Tatiane P.
dc.contributor.authorPetrovick, Pedro R.
dc.contributor.authorLyra, Ibson L.
dc.contributor.authorAraújo Júnior, Raimundo F.
dc.contributor.authorLangassner, Silvana Maria Zucolotto
dc.contributor.authorGuerra, Gerlane C. B.
dc.date.accessioned2018-06-16T11:38:13Z
dc.date.available2018-06-16T11:38:13Z
dc.date.issued2013
dc.description.resumoPhyllanthus niruri L., Euphorbiaceae, spray-dried standardized extract was studied for its anti-inflammatory and antinociceptive activities in adult albino rats and mice. The anti-inflammatory effect of spray-dried standardized extract was observed in carrageenan-induced paw edema and thioglycolate-induced leukocyte migration, while antinociceptive effects were observed using Randall & Selitto, tail flick, and hot plate tests. This study showed that intraperitoneal spray-dried standardized extract at 100, 200, 800, or 1600 mg/kg reduced the vascular response in the inflammatory process of paw edema induced by 1% carrageenan. Oral spray-dried standardized extract at 100 or 200 mg/kg inhibited leukocyte migration to the site of inflammation induced by 3% thioglycolate. In rats, at 100 and 200 mg/kg intraperitoneally, the extract exhibited a marked peripheral analgesic effect in a Randall & Selitto assay and showed significant central analgesic activity in a hot plate and tail flick assay. In conclusion, this study suggested that Phyllanthus niruri spray-dried standardized extract has potent inflammatory and antinociceptive activities and that these activities are not modified by standard drying process, making it feasible to use the dry extract standardized to obtain a phytotherapic preparation and thus validating its use for the treatment of pain and inflammation disorders.pt_BR
dc.identifier.citationARAÚJO, Aurigena Antunes de et al. Anti-infl ammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extract. Revista Brasileira de Farmacognosia, v. 23, p. 138-144, 2013. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-695X2013000100019>. Acesso em: 15 mar. 2018.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0102-695X2013005000004
dc.identifier.issn1981-528X
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/25417
dc.languageporpt_BR
dc.publisherSpringerpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectAntinociceptionpt_BR
dc.subjectAnti-inflammationpt_BR
dc.subjectPhyllanthus niruript_BR
dc.subjectStandardizationpt_BR
dc.titleAnti-infl ammatory and antinociceptive activities of Phyllanthus niruri spray-dried standardized extractpt_BR
dc.typearticlept_BR

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