Assessing the psychedelic "after-glow" in ayahuasca users: post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacities

Página do item simplificado Estatísticas
dc.contributor.authorSampedro, Frederic
dc.contributor.authorde la Fuente Revenga, Mario
dc.contributor.authorValle, Marta
dc.contributor.authorRoberto, Natalia
dc.contributor.authorDomínguez-Clavé, Elisabet
dc.contributor.authorElices, Matilde
dc.contributor.authorLuna, Luís Eduardo
dc.contributor.authorCrippa, José Alexandre S.
dc.contributor.authorHallak, Jaime E. C.
dc.contributor.authorAraújo, Dráulio Barros de
dc.contributor.authorFriedlander, Pablo
dc.contributor.authorBarker, Steven A.
dc.contributor.authorÁlvarez, Enrique
dc.contributor.authorSoler, Joaquim
dc.contributor.authorPascual, Juan C.
dc.contributor.authorFeilding, Amanda
dc.contributor.authorRiba, Jordi
dc.date.accessioned2017-06-27T14:32:33Z
dc.date.available2017-06-27T14:32:33Z
dc.date.issued2017-06-13
dc.description.resumoBACKGROUND: Ayahuasca is a plant tea containing the psychedelic 5-HT2A agonist N,N-dimethyltryptamine (DMT) and harmala monoamine-oxidase inhibitors. Acute administration leads to neurophysiological modifications in brain regions of the default mode network (DMN), purportedly through a glutamatergic mechanism. Post-acutely, ayahuasca potentiates mindfulness capacities in volunteers, and induces rapid and sustained antidepressant effects in treatment-resistant patients. However, the mechanisms underlying these fast and maintained effects are poorly understood. Here we investigated in an open-label uncontrolled study in sixteen healthy volunteers ayahuasca-induced post-acute neurometabolic and connectivity modifications, and their association with mindfulness measures. METHODS: Using 1H-magnetic resonance spectroscopy (MRS) and functional connectivity, we compared baseline and post-acute neurometabolites and seed-to-voxel connectivity in the posterior (PCC) and anterior (ACC) cingulate cortex after a single ayahuasca dose. RESULTS: MRS showed post-acute reductions in Glx (glutamate+glutamine), creatine and NAA-NAAG (N-acetylaspartate+N-acetylaspartylglutamate) in the PCC. Connectivity was increased between the PCC and the ACC, and between the ACC and limbic structures in the right medial temporal lobe (MTL). Glx reductions correlated with increases in the "Non-Judging" subscale of the Five Facets Mindfulness Questionnaire. Increased ACC-MTL connectivity correlated with increased scores on the Self-Compassion questionnaire. Post-acute neural changes predicted sustained elevations in "Non-Judging" two months later. CONCLUSIONS: These results support the involvement of glutamate neurotransmission in the effects of psychedelics in humans. They further suggest that neurometabolic changes in the PCC, a key region within the DMN, and increased connectivity between the ACC and MTL structures involved in emotion and memory, potentially underlie the post-acute psychological effects of ayahuasca.pt_BR
dc.identifier.doi10.1093/ijnp/pyx036
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23527
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectayahuascapt_BR
dc.subjecthumanpt_BR
dc.subjectmagnetic resonance imagingpt_BR
dc.subjectmindfulnesspt_BR
dc.subjectpsychedelic after-effectspt_BR
dc.titleAssessing the psychedelic "after-glow" in ayahuasca users: post-acute neurometabolic and functional connectivity changes are associated with enhanced mindfulness capacitiespt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
Assessing the Psychedelic After-Glow in Ayahuasca Users.pdf
Tamanho:
994.49 KB
Formato:
Adobe Portable Document Format
Descrição:
DraulioAraujo_ICe_Assessing the Psychedelic_2017
Imagem de Miniatura
 Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar

Coleções

ICe - Artigos publicados em periódicos
Repositório Institucional - UFRN Campus Universitário Lagoa NovaCEP 59078-970 Caixa postal 1524 Natal/RN - BrasilUniversidade Federal do Rio Grande do Norte© Copyright 2025. Todos os direitos reservados.
Contato+55 (84) 3342-2260 - R232Setor de Repositórios Digitaisrepositorio@bczm.ufrn.br
DSpaceIBICT
OasisBR
LAReferencia
Customizado pela CAT - BCZM