The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis

Azevedo, Kesley Pablo Morais de; Oliveira, Victor Hugo de; Medeiros, Gidyenne Christine Bandeira Silva de; Mata, Ádala Nayana de Sousa; García, Daniel Ángel; Martínez, Daniel Guillén; Leitão, José Carlos; Knackfuss, Maria Irany; Piuvezam, Grasiela

The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis

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dc.contributor.author	Azevedo, Kesley Pablo Morais de
dc.contributor.author	Oliveira, Victor Hugo de
dc.contributor.author	Medeiros, Gidyenne Christine Bandeira Silva de
dc.contributor.author	Mata, Ádala Nayana de Sousa
dc.contributor.author	García, Daniel Ángel
dc.contributor.author	Martínez, Daniel Guillén
dc.contributor.author	Leitão, José Carlos
dc.contributor.author	Knackfuss, Maria Irany
dc.contributor.author	Piuvezam, Grasiela
dc.date.accessioned	2021-01-05T13:03:38Z
dc.date.available	2021-01-05T13:03:38Z
dc.date.issued	2020-08-20
dc.description.resumo	The aim of this study was to analyze the evidence available in the literature about the effects of exercise on brain-derived neurotrophic factor levels in adolescents. The literature searches were conducted in PubMed, Embase, Scopus, ScienceDirect, Web of Science, SportDiscus, the Cochrane Central Register of Controlled Trials (CENTRAL) and CINAHL. Randomized controlled trials and non-randomized controlled trials performed with adolescents (10–19 years) who underwent different exercise programs and who evaluated BDNF levels before and after the intervention were included. We included six studies, four RCTs and two non-RCTs in the systematic review with a total of 407 adolescents. In two randomized trials and one non-RCT, the intervention groups showed significant improvements in BDNF levels compared with the control group. The results presented in the meta-analysis indicate that despite the positive effect in favor of the intervention, there were no significant differences (standardized mean difference 0.28 ng/mL, 95% confidence interval −0.28 to 0.85; p = 0.32, I2 = 0%). The results presented in our review indicate that aerobic exercise programs practiced in moderate- or high-intensity are promising strategies to increase BDNF levels in adolescents. However, further studies are required to support this finding	pt_BR
dc.identifier.citation	AZEVEDO, Kesley Pablo Morais de; OLIVEIRA, Victor Hugo de; MEDEIROS, Gidyenne Christine Bandeira Silva de; MATA, Ádala Nayana de Sousa; GARCÍA, Daniel Ángel; MARTÍNEZ, Daniel Guillén; LEITÃO, José Carlos; KNACKFUSS, Maria Irany; PIUVEZAM, Grasiela. The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis. International Journal of Environmental Research and Public Health, [s. l.], v. 17, p. 6056, 2020. Disponível em: https://www.mdpi.com/1660-4601/17/17/6056. Acesso em: 17 dez. 2020. https://doi.org/10.3390/ijerph17176056	pt_BR
dc.identifier.doi	10.3390/ijerph17176056
dc.identifier.issn	1660-4601
dc.identifier.uri	https://repositorio.ufrn.br/handle/123456789/31177
dc.language	en	pt_BR
dc.publisher	MDPI	pt_BR
dc.rights	Attribution 3.0 Brazil	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/br/	*
dc.subject	Exercise	pt_BR
dc.subject	Brain-derived neurotrophic factor	pt_BR
dc.subject	BDNF	pt_BR
dc.subject	Adolescent	pt_BR
dc.subject	Systematic review	pt_BR
dc.subject	Meta-analysis	pt_BR
dc.title	The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis	pt_BR
dc.type	article	pt_BR