Supplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model

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dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorSerquiz, Alexandre Coelho
dc.contributor.authorMachado, Richele Janaína de Araújo
dc.contributor.authorSerquiz, Raphael Paschoal
dc.contributor.authorLima, Vanessa Cristina Oliveira
dc.contributor.authorCarvalho, Fabiana Maria Coimbra de
dc.contributor.authorCarneiro, Marcella Araújo do Amaral
dc.contributor.authorUchôa, Adriana Ferreira
dc.contributor.authorSantos, Elizeu Antunes dos
dc.contributor.authorMorais, Ana Heloneida de Araújo
dc.date.accessioned2024-02-27T19:33:08Z
dc.date.available2024-02-27T19:33:08Z
dc.date.issued2016-02
dc.description.resumoIngestion of peanuts may have a beneficial effect on weight control, possibly due to the satietogenic action of trypsin inhibitors. The aim of this study was to isolate a new trypsin inhibitor in a typical Brazilian peanut sweet (pac¸oca) and evaluate its effect in biochemical parameters, weight gain and food intake in male Wistar rats. The trypsin inhibitor in peanut pac¸oca (AHTI) was isolated. Experimental diets were prepared with AIN-93G supplemented with AHTI. Animals had their weight and food intake monitored. Animals were anesthetized, euthanized, and their bloods collected by cardiac puncture for dosage of cholecystokinin (CCK) and other biochemical parameters. Supplementation with AHTI significantly decreased fasting glucose, body weight gain, and food intake. These effects may be attributed to increased satiety, once supplemented animals showed no evidence of impaired nutritional status and also because AHTI increased CCK production. Thus, our results indicate that AHTI, besides reducing fasting glucose, can reduce weight gain via food intake reductionpt_BR
dc.identifier.citationSERQUIZ, Alexandre Coelho; MACHADO, Richele Janaína de Araújo; SERQUIZ, Raphael Paschoal; LIMA, Vanessa Cristina Oliveira; CARVALHO, Fabiana Maria Coimbra de; CARNEIRO, Marcella Araújo do Amaral; MACIEL, Bruna Leal Lima; UCHÔA, Adriana Ferreira; SANTOS, Elizeu Antunes dos; MORAIS, Ana Heloneida de Araújo. Supplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal model. Journal Of Enzyme Inhibition and Medicinal Chemistry, [S.l.], v. 31, n. 6, p. 1261-1269, 29 fev. 2016. DOI: 10.3109/14756366.2015.1103236. Disponível em: https://www.tandfonline.com/doi/full/10.3109/14756366.2015.1103236. Acesso em: 01 fev. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3109/14756366.2015.1103236
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57692
dc.languageenpt_BR
dc.publisherJournal of Enzyme Inhibition and Medicinal Chemistrypt_BR
dc.subjectArachis hypogaea Lpt_BR
dc.subjectBioactive proteinspt_BR
dc.subjectObesitypt_BR
dc.subjectSatietypt_BR
dc.titleSupplementation with a new trypsin inhibitor from peanut is associated with reduced fasting glucose, weight control, and increased plasma CCK secretion in an animal modelpt_BR
dc.typearticlept_BR

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