Citocinas inflamatórias na distrofia muscular de Duchenne: uma revisão narrativa

Abstract

Objective: To describe the findings in the literature about inflammatory markers in Duchenne Muscular Dystrophy (DMD) and understand what is its association with disease progression. Bibliographic review: DMD is a severe genetic myopathy, characterized by an orthopedic, cardiac, and respiratory impairment, were it leads to the early death of the individual. Inflammation has a fundamental role in the pathophysiology of DMD. Elevated levels of cytokines and inflammatory markers, such as IL-1β, TNF-α, IL-6 and IL-17, activators and recruiters of inflammatory cells, seem to be related to the progression of the disease. Final considerations: Serum, tissue, and muscle levels of inflammatory markers were described as high in relation to healthy individuals. The association between inflammatory markers and the progression of DMD seems to be a peculiarity of the disease. Understanding this relationship is important for the establishment of new therapeutic approaches aimed at DMD. However, there is still a shortage on the subject in the literature. Therefore, there is a need for further related studies