Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments

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dc.contributor.authorCoimbra, Norberto Cysne
dc.contributor.authorSoares, Bruno Lobão
dc.contributor.authorCalvo, Fabrício
dc.contributor.authorAlmada, Rafael Carvalho
dc.contributor.authorFreitas, Renato Leonardo
dc.contributor.authorPaschoalin-Maurin, Tatiana
dc.contributor.authorAnjos-Garcia, Tayllon dos
dc.contributor.authorElias-Filho, Daoud Hibrahim
dc.contributor.authorUbiali, Walter Adriano
dc.contributor.authorTracey, Irene
dc.date.accessioned2022-10-26T20:57:10Z
dc.date.available2022-10-26T20:57:10Z
dc.date.issued2017-06-23
dc.description.resumoThe effects of endogenous opioid peptide antagonists on panic-related responses are controversial. Using elevated mazes and a prey-versus-predator paradigm, we investigated the involvement of the endogenous opioid peptide-mediated system in the modulation of anxiety- and panic attack-induced responses and innate fear-induced antinociception in the present work. Wistar rats were intraperitoneally pretreated with either physiological saline or naloxone at different doses and were subjected to either the elevated plus- or T-maze test or confronted by Crotalus durissus terrificus. The defensive behaviors of the rats were recorded in the presence of the predator and at 24 h after the confrontation, when the animals were placed in the experimental enclosure without the rattlesnake. The peripheral non-specific blockade of opioid receptors had a clear anxiolytic-like effect on the rats subjected to the elevated plus-maze but not on those subjected to the elevated T-maze; however, a clear panicolytic-like effect was observed, i.e., the defensive behaviors decreased, and the prey-versus-predator interaction responses evoked by the presence of the rattlesnakes increased. A similar effect was noted when the rats were exposed to the experimental context in the absence of the venomous snake. After completing all tests, the naloxone-treated groups exhibited less anxiety/fear-induced antinociception than the control group, as measured by the tail-flick test. These findings demonstrate the anxiolytic and panicolytic-like effects of opioid receptor blockade. In addition, the fearlessness behavior displayed by preys treated with naloxone at higher doses enhanced the defensive behavioral responses of venomous snakes.pt_BR
dc.identifier.citationCOIMBRA, Norberto Cysne et al. Opioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environments. Neuroscience, v. 354, p. 178-195, 2017. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0306452217302907?via%3Dihub>. Acesso em: 26 mar. 2018.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.neuroscience.2017.04.032
dc.identifier.issn0306-4522
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/49633
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectinnate fearpt_BR
dc.subjectconditioned fear/anticipatory anxietypt_BR
dc.subjectpanic attackspt_BR
dc.subjectendogenous opioid peptide-mediated neural systempt_BR
dc.subjectprey-versus-rattlesnake pit viper paradigmpt_BR
dc.subjectinstinctive fear-induced antinociceptionpt_BR
dc.titleOpioid neurotransmission modulates defensive behavior and fear-induced antinociception in dangerous environmentspt_BR
dc.typearticlept_BR

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