Sex-biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus) and potential behavioral correlates

Nogueira, Viviane Brito; Imparato, Danilo Oliveira; Souza, Sandro José de; Sousa, Maria Bernardete Cordeiro de

Sex-biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus) and potential behavioral correlates

Página do item simplificado Estatísticas

dc.contributor.author	Nogueira, Viviane Brito
dc.contributor.author	Imparato, Danilo Oliveira
dc.contributor.author	Souza, Sandro José de
dc.contributor.author	Sousa, Maria Bernardete Cordeiro de
dc.date.accessioned	2019-01-08T16:46:44Z
dc.date.available	2019-01-08T16:46:44Z
dc.date.issued	2018-12
dc.description.resumo	INTRODUCTION: The common marmoset (Callithrix jacchus), a small New World monkey, has been widely used as a biological model in neuroscience to elucidate neural circuits involved in cognition and to understand brain dysfunction in neuropsychiatric disorders. In this regard, the availability of gene expression data derived from next-generation sequencing (NGS) technologies represents an opportunity for a molecular contextualization. Sexual dimorphism account for differences in diseases prevalence and prognosis. Here, we explore sex differences on frontal cortex of gene expression in common marmoset's adults. METHODS: Gene expression profiles in six different tissues (cerebellum, frontal cortex, liver, heart, and kidney) were analyzed in male and female marmosets. To emphasize the translational value of this species for behavioral studies, we focused on sex-biased gene expression from the frontal cortex of male and female in common marmosets and compared to humans (Homo sapiens). RESULTS: In this study, we found that frontal cortex genes whose expression is male-biased are conserved between marmosets and humans and enriched with "house-keeping" functions. On the other hand, female-biased genes are more related to neural plasticity functions involved in remodeling of synaptic circuits, stress cascades, and visual behavior. Additionally, we developed and made available an application-the CajaDB-to provide a friendly interface for genomic, expression, and alternative splicing data of marmosets together with a series of functionalities that allow the exploration of these data. CajaDB is available at cajadb.neuro.ufrn.br. CONCLUSION: The data point to differences in gene expression of male and female common marmosets in all tissues analyzed. In frontal cortex, female-biased expression in synaptic plasticity, stress, and visual processing might be linked to biological and behavioral mechanisms of this sex. Due to the limited sample size, the data here analyzed are for exploratory purposes.	pt_BR
dc.identifier.citation	NOGUEIRA, V. B. et al. Sex‐biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus) and potential behavioral correlates. Brain and Behavior, v. 8, n. 12, p. e01148, dez. 2018. doi: 10.1002/brb3.1148	pt_BR
dc.identifier.doi	10.1002/brb3.1148
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/26430
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Adaptive strategies	pt_BR
dc.subject	database	pt_BR
dc.subject	neuropsychiatric primate model	pt_BR
dc.subject	sexual dimorphism	pt_BR
dc.subject	synaptic plasticity	pt_BR
dc.subject	transcriptomics	pt_BR
dc.title	Sex-biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus) and potential behavioral correlates	pt_BR
dc.type	article	pt_BR