Selenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseases

dc.contributor.authorEvangelista, Karine Cavalcanti Maurício de Sena
dc.contributor.authorFerreira, Rannapaula Lawrynhuk Urbano
dc.contributor.authorAzevedo, Eduardo Pereira de
dc.contributor.authorPinheiro, Francisco Irochima
dc.contributor.authorCobucci, Ricardo Ney
dc.contributor.authorPedrosa, Lucia Fatima Campos
dc.date.accessioned2024-08-23T19:30:55Z
dc.date.available2024-08-23T19:30:55Z
dc.date.issued2021-06
dc.description.resumoThis review covers current knowledge of selenium in the dietary intake, its bioavailability, metabolism, functions, biomarkers, supplementation and toxicity, as well as its relationship with diseases and gut microbiota specifically on the symbiotic relationship between gut microflora and selenium status. Selenium is essential for the maintenance of the immune system, conversion of thyroid hormones, protection against the harmful action of heavy metals and xenobiotics as well as for the reduction of the risk of chronic diseases. Selenium is able to balance the microbial flora avoiding health damage associated with dysbiosis. Experimental studies have shown that inorganic and organic selenocompounds are metabolized to selenomethionine and incorporated by bacteria from the gut microflora, therefore highlighting their role in improving the bioavailability of selenocompounds. Dietary selenium can affect the gut microbial colonization, which in turn influences the host’s selenium status and expression of selenoproteoma. Selenium deficiency may result in a phenotype of gut microbiota that is more susceptible to cancer, thyroid dysfunctions, inflammatory bowel disease, and cardiovascular disorders. Although the host and gut microbiota benefit each other from their symbiotic relationship, they may become competitors if the supply of micronutrients is limited. Intestinal bacteria can remove selenium from the host resulting in two to three times lower levels of host’s selenoproteins under selenium-limiting conditions. There are still gaps in whether these consequences are unfavorable to humans and animals or whether the daily intake of selenium is also adapted to meet the needs of the bacteriapt_BR
dc.identifier.citationFERREIRA, Rannapaula Lawrynhuk Urbano; EVANGELISTA, Karine Cavalcanti Maurício de Sena; AZEVEDO, Eduardo Pereira de; PINHEIRO, Francisco Irochima; COBUCCI, Ricardo Ney; PEDROSA, Lucia Fatima Campos. Selenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseases. Frontiers in Nutrition, [S.l.], v. 8, p. 1-19, 4 jun. 2021. DOI: 10.3389/fnut.2021.685317. Disponível em: https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2021.685317/full. Acesso em: 25 jul. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3389/fnut.2021.685317
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59846
dc.languageenpt_BR
dc.publisherFrontiers in Nutritionpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectSeleniumpt_BR
dc.subjectGut microbiotapt_BR
dc.subjectSelenocompoundspt_BR
dc.subjectSelenoproteinspt_BR
dc.subjectSelenium metabolismpt_BR
dc.titleSelenium in human health and gut microflora: bioavailability of selenocompounds and relationship with diseasespt_BR
dc.typearticlept_BR

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