Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation

dc.contributor.author	Almeida‑Filho, Daniel G.
dc.contributor.author	Queiroz, Claudio Marcos Teixeira de
dc.contributor.author	Ribeiro, Sidarta Tollendal Gomes
dc.date.accessioned	2018-07-30T12:56:36Z
dc.date.available	2018-07-30T12:56:36Z
dc.date.issued	2018-07-19
dc.description.resumo	Once viewed as a passive physiological state, sleep is a heterogeneous and complex sequence of brain states with essential efects on synaptic plasticity and neuronal functioning. Rapid-eye-movement (REM) sleep has been shown to promote calcium-dependent plasticity in principal neurons of the cerebral cortex, both during memory consolidation in adults and during post-natal development. This article reviews the plasticity mechanisms triggered by REM sleep, with a focus on the emerging role of kinases and immediate-early genes for the progressive corticalization of hippocampus-dependent memories. The body of evidence suggests that memory corticalization triggered by REM sleep is a systemic phenomenon with cellular and molecular causes.	pt_BR
dc.identifier.doi	10.1007/s00018-018-2886-9
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/25632
dc.language	por	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Plasticity	pt_BR
dc.subject	Long-term memory	pt_BR
dc.subject	Ofine consolidation	pt_BR
dc.subject	Trace propagation	pt_BR
dc.subject	Cortical engagement	pt_BR
dc.title	Memory corticalization triggered by REM sleep: mechanisms of cellular and systems consolidation	pt_BR
dc.type	article	pt_BR