Neuronal Assembly Detection and Cell Membership Specification by Principal Component Analysis

dc.contributor.authorLopes-dos-Santos, Vítor
dc.contributor.authorConde-Ocazionez, Sergio
dc.contributor.authorNicolelis, Miguel A. L.
dc.contributor.authorRibeiro, Sidarta Tollendal Gomes
dc.contributor.authorTort, Adriano Bretanha Lopes
dc.date.accessioned2013-02-18T19:43:30Z
dc.date.available2013-02-18T19:43:30Z
dc.date.issued2011
dc.descriptionLOPES-DOS-SANTOS, V. , CONDE-OCAZIONEZ, S. ; NICOLELIS, M. A. L. , RIBEIRO, S. T. , TORT, A. B. L. . Neuronal assembly detection and cell membership specification by principal component analysis. Plos One, v. 6, p. e20996, 2011.pt_BR
dc.description.abstractIn 1949, Donald Hebb postulated that assemblies of synchronously activated neurons are the elementary units of information processing in the brain. Despite being one of the most influential theories in neuroscience, Hebb’s cell assembly hypothesis only started to become testable in the past two decades due to technological advances. However, while the technology for the simultaneous recording of large neuronal populations undergoes fast development, there is still a paucity of analytical methods that can properly detect and track the activity of cell assemblies. Here we describe a principal component-based method that is able to (1) identify all cell assemblies present in the neuronal population investigated, (2) determine the number of neurons involved in ensemble activity, (3) specify the precise identity of the neurons pertaining to each cell assembly, and (4) unravel the time course of the individual activity of multiple assemblies. Application of the method to multielectrode recordings of awake and behaving rats revealed that assemblies detected in the cerebral cortex and hippocampus typically contain overlapping neurons. The results indicate that the PCA method presented here is able to properly detect, track and specify neuronal assemblies, irrespective of overlapping membership.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior, Conselho Nacional de Desenvolvimento Científico e Tecnológico, e Associação Alberto Santos Dumont para Apoio à Pesquisa.pt_BR
dc.identifier.citationLopes-dos-Santos V., Conde-Ocazionez S., Nicolelis, M. A. L., Ribeiro, S. T., Tort, A. B. L. (2011)pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/1/6194
dc.language.isoengpt_BR
dc.rightsAcesso Abertopt_BR
dc.titleNeuronal Assembly Detection and Cell Membership Specification by Principal Component Analysispt_BR
dc.typearticlept_BR

Arquivos

Pacote Original

Agora exibindo 1 - 1 de 1
Carregando...
Imagem de Miniatura
Nome:
AdrianoBLTort_ICE_Neuronal2011.pdf
Tamanho:
1.45 MB
Formato:
Adobe Portable Document Format
Carregando...
Imagem de Miniatura
Baixar

Licença do Pacote

Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
license.txt
Tamanho:
1.71 KB
Formato:
Item-specific license agreed upon to submission
Nenhuma Miniatura disponível
Baixar