Neuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorders

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dc.contributor.authorRuggiero, Rafael Naime
dc.contributor.authorRossignoli, Matheus Teixeira
dc.contributor.authorMarques, Danilo Benette
dc.contributor.authorSousa, Bruno Monteiro de
dc.contributor.authorRomcy-Pereira, Rodrigo Neves
dc.contributor.authorLopes-Aguiar, Cleiton
dc.contributor.authorLeite, João Pereira
dc.date.accessioned2021-11-30T14:15:57Z
dc.date.available2021-11-30T14:15:57Z
dc.date.issued2021-10-11
dc.description.resumoThe hippocampus-prefrontal cortex (HPC-PFC) pathway plays a fundamental role in executive and emotional functions. Neurophysiological studies have begun to unveil the dynamics of HPC-PFC interaction in both immediate demands and longterm adaptations. Disruptions in HPC-PFC functional connectivity can contribute to neuropsychiatric symptoms observed in mental illnesses and neurological conditions, such as schizophrenia, depression, anxiety disorders, and Alzheimer’s disease. Given the role in functional and dysfunctional physiology, it is crucial to understand the mechanisms that modulate the dynamics of HPC-PFC communication. Two of the main mechanisms that regulate HPC-PFC interactions are synaptic plasticity and modulatory neurotransmission. Synaptic plasticity can be investigated inducing longterm potentiation or long-term depression, while spontaneous functional connectivity can be inferred by statistical dependencies between the local field potentials of both regions. In turn, several neurotransmitters, such as acetylcholine, dopamine, serotonin, noradrenaline, and endocannabinoids, can regulate the fine-tuning of HPC-PFC connectivity. Despite experimental evidence, the effects of neuromodulation on HPCPFC neuronal dynamics from cellular to behavioral levels are not fully understood. The current literature lacks a review that focuses on the main neurotransmitter interactions with HPC-PFC activity. Here we reviewed studies showing the effects of the main neurotransmitter systems in long- and short-term HPC-PFC synaptic plasticity. We also looked for the neuromodulatory effects on HPC-PFC oscillatory coordination. Finally, we review the implications of HPC-PFC disruption in synaptic plasticity and functional connectivity on cognition and neuropsychiatric disorders. The comprehensive overview of these impairments could help better understand the role of neuromodulation in HPC-PFC communication and generate insights into the etiology and physiopathology of clinical conditionspt_BR
dc.identifier.citationRUGGIERO, Rafael Naime; ROSSIGNOLI, Matheus Teixeira; MARQUES, Danilo Benette; SOUSA, Bruno Monteiro de; ROMCY-PEREIRA, Rodrigo Neves; LOPES-AGUIAR, Cleiton; LEITE, João Pereira. Neuromodulation of Hippocampal-Prefrontal Cortical Synaptic Plasticity and Functional Connectivity: implications for neuropsychiatric disorders. Frontiers In Cellular Neuroscience, [S. l.], v. 15, p. 1-23, 11 out. 2021. DOI: https://doi.org/10.3389/fncel.2021.732360pt_BR
dc.identifier.doi10.3389/fncel.2021.732360
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45095
dc.languageenpt_BR
dc.publisherFrontiers In Cellular Neurosciencept_BR
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/br/*
dc.subjectHippocampuspt_BR
dc.subjectPrefrontal cortexpt_BR
dc.subjectLong-term potentiation (LTP)pt_BR
dc.subjectLong-term depression (LTD)pt_BR
dc.subjectLocal field potential (LFP)pt_BR
dc.subjectAcetylcholinept_BR
dc.subjectMonoaminespt_BR
dc.subjectCannabinoidspt_BR
dc.titleNeuromodulation of hippocampal-prefrontal cortical synaptic plasticity and functional connectivity: implications for neuropsychiatric disorderspt_BR
dc.typearticlept_BR

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