Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish

dc.contributor.authorSilva, Jaquelinne Pinheiro da
dc.contributor.authorTran, Steven
dc.contributor.authorSilva, Priscila Fernandes
dc.contributor.authorLuchiari, Ana Carolina
dc.date.accessioned2018-01-08T14:14:54Z
dc.date.available2018-01-08T14:14:54Z
dc.date.issued2017-06-23
dc.description.resumoLearning and memory are vital to an animal's survival, and numerous factors can disrupt cognitive performance. Sleep is an evolutionarily conserved physiological process known to be important for the consolidation of learning and memory. The zebrafish has emerged as a powerful model organism sharing organizational and functional characteristics with other vertebrates, providing great translational relevance. In our study, we used a simple spatial associative learning task to quantify the effects of sleep deprivation (partial vs. total) on learning performance in zebrafish, using an animated conspecific shoal image as a reward. Control animals maintained on a regular light:dark cycle were able to acquire the association between the unconditioned and conditioned stimulus, reinforcing zebrafish as a valid and reliable model for appetitive conditioning tasks. Notably, sleep deprivation did not alter the perception of and response to the conspecific image. In contrast, although partial sleep deprivation did not impair cognitive performance, total sleep deprivation significantly impaired performance on the associative learning task. Our results suggest that sleep is important for learning and memory, and that the effects of sleep deprivation on these processes can be investigated in zebrafishpt_BR
dc.identifier.citationSILVA, Jaquelinne Pinheiro da; et al. Good night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafish. Pharmacology Biochemistry and Behavior, v. 1, p. 11-19, jun. 2017. Disponível em:<http://www.sciencedirect.com/science/article/pii/S0091305716303148?via%3Dihub>. Acesso em: 16 out. 2017.pt_BR
dc.identifier.issn0091-3057
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/24534
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectLearningpt_BR
dc.subjectMemorypt_BR
dc.subjectAssociative learning taskpt_BR
dc.subjectSleeppt_BR
dc.subjectSocial rewardpt_BR
dc.titleGood night, sleep tight: the effects of sleep deprivation on spatial associative learning in zebrafishpt_BR
dc.typearticlept_BR

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