The impact of essential and toxic elements on cardiometabolic risk factors in adults and older people

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dc.contributor.authorLima, Severina Carla Vieira Cunha
dc.contributor.authorNunes, Francisca Leide da Silva
dc.contributor.authorLyra, Clélia de Oliveira
dc.contributor.authorMarchioni, Dirce Maria
dc.contributor.authorPedrosa, Lucia Fatima Campos
dc.contributor.authorBarbosa Júnior, Fernando Barbosa
dc.contributor.authorEvangelista, Karine Cavalcanti Maurício Sena
dc.contributor.authorIDhttps://orcid.org/0000-0001-8268-1986pt_BR
dc.date.accessioned2025-02-07T20:26:26Z
dc.date.available2025-02-07T20:26:26Z
dc.date.issued2022
dc.description.resumoBackground and aim Evidence suggests an association between essential and toxic elements and the worsening of cardiometabolic risk factors. This study aimed to investigate the concentrations of zinc, copper, selenium, arsenic, cadmium, and mercury and their relationship with cardiometabolic risk factors in adults and older people. Methods: This cross-sectional study was carried out with 112 adults with a mean age of 59 (sd 14) years old and a BMI of 29.30 (sd 5.11) Kg/m2. The subject’s weight and height were measured for body mass index (BMI) calculation, classified according to the cut-off points recommended by the World Health Organization (WHO). We evaluated sociodemographic, clinical, lifestyle, waist circumference – WC, visceral adiposity index - VAI, glycemic lipid profile, blood pressure, and high-sensitive C-reactive protein (hs-CRP). Cardiovascular risk was defined by The Global Risk Score (GRS) score. Plasma zinc, selenium, copper levels, urinary arsenic, cadmium, and mercury levels were measured using the inductively coupled plasma mass spectrometry technique (ICP-MS). Results: There was a negative association between urinary arsenic and VAI (β − 0.03, p < 0.01), triglycerides (β − 1.10, p < 0.01), and VLDL cholesterol (β − 0.14, p = 0.02). Plasma copper and copper/zinc ratio were positively associated with fasting glucose and hs-CRP (β 0.38, p < 0.01; β 36.02, p = 0.01, β 0.004, p < 0.01, β 0.68, p < 0.001, respectively). Urinary arsenic (β − 0.14, p = 0.04) and cadmium (β − 36.42, p = 0.04) were negatively associated with systolic blood pressure. Also, urinary cadmium was negatively associated with diastolic blood pressure (β − 21.55, p = 0.03), and urinary mercury showed an opposite behavior (β 1.45, p = 0.03). Conclusion: Essential and toxic elements in urine and plasma could be potential biomarkers for cardiovascular risk factors. A healthy lifestyle should be adopted; in addition, government policies should be developed to guarantee sustainable production and a safe environment.pt_BR
dc.identifier.citationNUNES, Francisca Leide da Silva; LIMA, Severina Carla Vieira Cunha; LYRA,Clélia de Oliveira; MARCHIONI, Dirce Maria; PEDROSA, Lucia Fatima Campos; BARBOSA JUNIOR, Fernando; EVANGELISTA, Karine Cavalcanti Maurício Sena. The impact of essential and toxic elements on cardiometabolic risk factors in adults and older people. Journal of trace elements in medicine and biology, v. 72, p. 126991, 2022. DOI: https://doi.org/10.1016/j.jtemb.2022.126991. Disponível em: https://pubmed.ncbi.nlm.nih.gov/35597099/. Acesso em 02 dez. 2024.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.jtemb.2022.126991
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/62591
dc.languageenpt_BR
dc.publisherJournal of trace elements in medicine and biologypt_BR
dc.subjectTrace elementspt_BR
dc.subjectHeavy metalspt_BR
dc.subjectHyperglycemiapt_BR
dc.subjectDyslipidemiapt_BR
dc.subjectHypertensionpt_BR
dc.subjectCardiovascular riskpt_BR
dc.titleThe impact of essential and toxic elements on cardiometabolic risk factors in adults and older peoplept_BR
dc.typearticlept_BR

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