A quantitative textual analysis of the subjective effects of ayahuasca in naïve users with and without depression

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dc.contributor.authorCruz, Lucas
dc.contributor.authorBienemann, Bheatrix
dc.contributor.authorFontes, Fernanda Palhano Xavier de
dc.contributor.authorTófoli, Luís Fernando
dc.contributor.authorAraujo, Draulio Barros de
dc.contributor.authorMograbi, Daniel Correa
dc.date.accessioned2023-11-24T15:16:26Z
dc.date.available2023-11-24T15:16:26Z
dc.date.issued2023-11
dc.description.resumoAyahuasca is a brew with psychoactive properties that has been used as an entheogen for centuries, with more recent studies suggesting it is a promising treatment for some clinical disorders. Although there is an emerging scientific literature on its effects, to the best of our knowledge no study has explored the self-reported experiences of first-time ayahuasca users with quantitative textual analysis tools. Accordingly, the current study aimed to analyze the subjective experience of naive individuals with depression and healthy controls after consuming ayahuasca. For this purpose, responses from a subsample of participants from a previous clinical trial to open-ended questions regarding their experience with ayahuasca underwent textual analysis. Data from nine patients with treatment-resistant depression and 20 healthy individuals were included, and quantitative textual analysis was performed using IRaMuTeQ 0.7 alpha 2 and R 3.1.2. The analysis identified five clusters: alterations in the state of consciousness, cognitive changes, somatic alterations, auditory experiences, and visual perceptual content. Additionally, findings suggest specific features of the experience of people with depression with ayahuasca, such as increased aversive bodily reactions. The results are consistent with previous findings indicating central axes of the psychedelic experience, and may inform therapeutic approaches using ayahuascapt_BR
dc.identifier.citationCRUZ, Lucas; BIENEMANN, Bheatrix; PALHANO-FONTES, Fernanda; TÓFOLI, Luís Fernando; ARAUJO, Draulio B.; MOGRABI, Daniel C. A quantitative textual analysis of the subjective effects of ayahuasca in naïve users with and without depression. Scientific Reports, [S. l.], v. 13, n. 1, p. 19635, nov. 2023. DOI http://dx.doi.org/10.1038/s41598-023-44193-5. Disponível em: https://www.nature.com/articles/s41598-023-44193-5. Acesso em: 22 nov. 2023pt_BR
dc.identifier.doi10.1038/s41598-023-44193-5
dc.identifier.issn2045-2322
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55425
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectayahuasca - subjective effectspt_BR
dc.subjectbanisteriopsispt_BR
dc.subjectdimethyltryptaminept_BR
dc.subjectN,N-Dimethyltryptaminept_BR
dc.subjectpsychedelicpt_BR
dc.subjectquantitative textual analysispt_BR
dc.subjecttherapeutic approachespt_BR
dc.titleA quantitative textual analysis of the subjective effects of ayahuasca in naïve users with and without depressionpt_BR
dc.typearticlept_BR

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