Detection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patients

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dc.contributor.authorSoares, Rosilene Calazans
dc.contributor.authorOliveira, Márcio Campos de
dc.contributor.authorSouza, Lélia Batista de
dc.contributor.authorCosta, Antonio de Lisboa Lopes
dc.contributor.authorPinto, Leão Pereira
dc.date.accessioned2017-09-13T15:25:53Z
dc.date.available2017-09-13T15:25:53Z
dc.date.issued2008
dc.description.resumoThis study investigated the presence of human papillomavirus (HPV) DNA and viral types in 33 cases of oral squamous cells carcinoma (OSCC) and compared the immunohistochemical expression of the cell-cycle markers p21 and pRb between cases of the disease with and without HPV. DNA was extracted from paraffin-embedded tissue and amplified by PCR for the detection of HPV DNA. Viral typing was performed by dot blot hybridization. Immunohistochemistry was performed by the streptavidin-biotin technique. HPV DNA was detected in 11 (33.33%) of the 33 cases. The prevalent viral type was HPV 18 (81.81%). A significant association was observed between the presence of HPV and immunohistochemical expression of pRb, but not between p21 expression and the presence of the virus. The low frequency of detection of HPV DNA in OSCC suggests a possible participation of the virus in the development and progression of only a subgroup of these tumors.pt_BR
dc.identifier.citationSOARES, Rosilene Calazans et al . Detection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patients. Journal of Applied Oral Science, v. 16, n. 5, p. 340-344, 2008.pt_BR
dc.identifier.doi10.1590/S1678-77572008000500007
dc.identifier.urihttps://repositorio.ufrn.br/jspui/handle/123456789/23862
dc.languageengpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectDNA Probespt_BR
dc.subjectHPVpt_BR
dc.subjectCarcinomapt_BR
dc.subjectSquamous cell cancerpt_BR
dc.subjectPolymerase Chain Reactionpt_BR
dc.subjectHybridizationpt_BR
dc.subjectCell cyclept_BR
dc.titleDetection of HPV DNA and immunohistochemical expression of cell cycle proteins in oral carcinoma in a population of brazilian patientspt_BR
dc.typearticlept_BR

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