Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis
dc.contributor.author | Almeida, Jose Bruno de | |
dc.contributor.author | Brito, Tereza Neuma Souza | |
dc.contributor.author | Vilar, Maria José | |
dc.contributor.author | Faria, Ana Luiza Souza Brito | |
dc.contributor.author | Medeiros, Sarah Dantas Viana | |
dc.contributor.author | Medeiros, Maria Carmo Cardoso | |
dc.contributor.author | Silva, Edna Marques Araújo | |
dc.contributor.author | Silva, Vanessa Marques Araújo | |
dc.contributor.author | Souza, Luanda Bárbara Ferreira Canário | |
dc.contributor.author | Arruda, Luisa Karla P | |
dc.contributor.author | Costa, Tatiana Xavier | |
dc.contributor.author | Cavalcanti Junior, Geraldo Barroso | |
dc.contributor.author | Oliveira, Antonio Gouveia | |
dc.contributor.author | Sales, Valéria Soraya Farias | |
dc.date.accessioned | 2023-08-02T19:55:03Z | |
dc.date.available | 2023-08-02T19:55:03Z | |
dc.date.issued | 2014 | |
dc.description.resumo | Background: Urine is increasingly becoming an attractive biological fluid in clinical practice due to being an easily obtained, non-invasive sampling method, containing proteins and peptides. The aim of this study was to investigate eosinophiluria, urinary eosinophil cationic protein (uECP) and urinary IL-5 (uIL-5) in patients with Lupus Nephritis. Methods: Seventy-four patients with SLE—20 with clinical and laboratory evidence of lupus nephritis (LN group) and 54 without evidence of renal involvement (non-LN group)—were analyzed regarding eosinophiluria, uECP and uIL-5. Eosinophiluria was observed by Hansel's stain, ECP by fluoroenzymeimmunoassay and uIL-5 by quantitative sandwich enzyme immunoassay. Both uECP and urinary IL-5 (uIL-5) were corrected by urinary creatinine. Eosinophiluria and uECP were compared with glomerular erythrocyturia, protein/creatinine ratio (Pr/Cr ratio), serum creatinine, estimated glomerular filtration rate (eGFR), anti-double-stranded DNA (anti-dsDNA), serum levels of complement (C3 and C4), uIL-5/Cr ratio, and SLE disease activity index. Results: Patients of the LN group had higher eosinophiluria, uECP, uECP/Cr ratio levels, and uIL-5 than patients of the non-LN group (p<0.001 for all). These variables showed a statistically significant correlation with glomerular erythrocyturia, casts, Pr/Cr ratio, serum creatinine, eGFR, anti-dsDNA, uIL-5/Cr, and SLE disease activity index (all p<0.05). Conclusion: These results provide evidence of increased urinary eosinophils, ECP and IL-5 in patients with SLE and LN; uECP/Cr ratio showed better correlation with markers of renal function and SLE disease activity | pt_BR |
dc.identifier.citation | ALMEIDA, José Bruno de, et al. Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis. Allergy, Asthma & Clinical Immunology, [S.L.], v. 10, n. 1, p. 1, dez. 2014. Springer Science and Business Media LLC. http://dx.doi.org/10.1186/s13223-014-0061-x. Disponível em: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-014-0061-x. Acesso em: 27 jul. 2023. | pt_BR |
dc.identifier.doi | http://dx.doi.org/10.1186/s13223-014-0061-x | |
dc.identifier.uri | https://repositorio.ufrn.br/handle/123456789/54345 | |
dc.language | en | pt_BR |
dc.publisher | Allergy, Asthma & Clinical Immunology | pt_BR |
dc.rights | Attribution 3.0 Brazil | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/br/ | * |
dc.subject | eosinophils | pt_BR |
dc.subject | systemic lupus erythematosus | pt_BR |
dc.subject | eosinophil cationic protein | pt_BR |
dc.subject | interleukin-5 | pt_BR |
dc.title | Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis | pt_BR |
dc.type | article | pt_BR |
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