Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis

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dc.contributor.authorAlmeida, Jose Bruno de
dc.contributor.authorBrito, Tereza Neuma Souza
dc.contributor.authorVilar, Maria José
dc.contributor.authorFaria, Ana Luiza Souza Brito
dc.contributor.authorMedeiros, Sarah Dantas Viana
dc.contributor.authorMedeiros, Maria Carmo Cardoso
dc.contributor.authorSilva, Edna Marques Araújo
dc.contributor.authorSilva, Vanessa Marques Araújo
dc.contributor.authorSouza, Luanda Bárbara Ferreira Canário
dc.contributor.authorArruda, Luisa Karla P
dc.contributor.authorCosta, Tatiana Xavier
dc.contributor.authorCavalcanti Junior, Geraldo Barroso
dc.contributor.authorOliveira, Antonio Gouveia
dc.contributor.authorSales, Valéria Soraya Farias
dc.date.accessioned2023-08-02T19:55:03Z
dc.date.available2023-08-02T19:55:03Z
dc.date.issued2014
dc.description.resumoBackground: Urine is increasingly becoming an attractive biological fluid in clinical practice due to being an easily obtained, non-invasive sampling method, containing proteins and peptides. The aim of this study was to investigate eosinophiluria, urinary eosinophil cationic protein (uECP) and urinary IL-5 (uIL-5) in patients with Lupus Nephritis. Methods: Seventy-four patients with SLE—20 with clinical and laboratory evidence of lupus nephritis (LN group) and 54 without evidence of renal involvement (non-LN group)—were analyzed regarding eosinophiluria, uECP and uIL-5. Eosinophiluria was observed by Hansel's stain, ECP by fluoroenzymeimmunoassay and uIL-5 by quantitative sandwich enzyme immunoassay. Both uECP and urinary IL-5 (uIL-5) were corrected by urinary creatinine. Eosinophiluria and uECP were compared with glomerular erythrocyturia, protein/creatinine ratio (Pr/Cr ratio), serum creatinine, estimated glomerular filtration rate (eGFR), anti-double-stranded DNA (anti-dsDNA), serum levels of complement (C3 and C4), uIL-5/Cr ratio, and SLE disease activity index. Results: Patients of the LN group had higher eosinophiluria, uECP, uECP/Cr ratio levels, and uIL-5 than patients of the non-LN group (p<0.001 for all). These variables showed a statistically significant correlation with glomerular erythrocyturia, casts, Pr/Cr ratio, serum creatinine, eGFR, anti-dsDNA, uIL-5/Cr, and SLE disease activity index (all p<0.05). Conclusion: These results provide evidence of increased urinary eosinophils, ECP and IL-5 in patients with SLE and LN; uECP/Cr ratio showed better correlation with markers of renal function and SLE disease activitypt_BR
dc.identifier.citationALMEIDA, José Bruno de, et al. Measuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritis. Allergy, Asthma & Clinical Immunology, [S.L.], v. 10, n. 1, p. 1, dez. 2014. Springer Science and Business Media LLC. http://dx.doi.org/10.1186/s13223-014-0061-x. Disponível em: https://aacijournal.biomedcentral.com/articles/10.1186/s13223-014-0061-x. Acesso em: 27 jul. 2023.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1186/s13223-014-0061-x
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/54345
dc.languageenpt_BR
dc.publisherAllergy, Asthma & Clinical Immunologypt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjecteosinophilspt_BR
dc.subjectsystemic lupus erythematosuspt_BR
dc.subjecteosinophil cationic proteinpt_BR
dc.subjectinterleukin-5pt_BR
dc.titleMeasuring eosinophiluria, urinary eosinophil cationic protein and urinary interleukin-5 in patients with Lupus Nephritispt_BR
dc.typearticlept_BR

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