Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse

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dc.contributor.authorRadiske, Andressa
dc.contributor.authorCastro, Carla Miranda de
dc.contributor.authorRossato, Janine Inez
dc.contributor.authorGonzalez, Maria Carolina
dc.contributor.authorCammarota, Martín Pablo
dc.date.accessioned2023-12-26T16:16:58Z
dc.date.available2023-12-26T16:16:58Z
dc.date.issued2023-12
dc.description.resumoHippocampal GluN2B subunit-containing NMDAR (GluN2B-NMDAR) activation during recall destabilizes fear extinction memory, which must undergo brain-derived neurotrophic factor (BDNF)-dependent reconsolidation to persist. Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a Ser/Thr protein kinase essential for hippocampus-dependent memory processing that acts downstream GluN2B-NMDAR and controls BDNF expression, but its participation in fear extinction memory reconsolidation has not yet been studied. Using a combination of pharmacological and behavioral tools, we found that in adult male Wistar rats, intra dorsal-CA1 administration of the CaMKII inhibitors autocamtide-2-related inhibitory peptide (AIP) and KN-93, but not of their inactive analogs scrambled AIP and KN-92, after fear extinction memory recall impaired extinction and caused GluN2B-NMDAR-dependent recovery of fear. Our results indicate that hippocampal CaMKII is necessary for fear extinction reconsolidation, and suggest that modulation of its activity around the time of recall controls the inhibition that extinction exerts on learned fearpt_BR
dc.identifier.citationRADISKE, Andressa; CASTRO, Carla Miranda de; ROSSATO, Janine I.; GONZALEZ, Maria Carolina; CAMMAROTA, Martín. Hippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapse. Scientific Reports, [S. l.], v. 13, n. 1, p. 21712, dez. 2023. Doi: http://dx.doi.org/10.1038/s41598-023-48454-1. Disponível em: https://www.nature.com/articles/s41598-023-48454-1. Acesso em: 26 dez. 2023pt_BR
dc.identifier.doi10.1038/s41598-023-48454-1
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/56922
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCalcium-Calmodulin-Dependent Protein Kinase Type 2pt_BR
dc.subjectHippocampal CaMKII - Fear extinction reconsolidationpt_BR
dc.subjectHippocampal CaMKII - Extinction memory reconsolidationpt_BR
dc.titleHippocampal CaMKII inhibition induces reactivation-dependent amnesia for extinction memory and causes fear relapsept_BR
dc.typearticlept_BR

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