Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

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dc.contributor.authorHoskin, Roberta Targino
dc.contributor.authorPambianchi, Erika
dc.contributor.authorPecorelli, Alessandra
dc.contributor.authorGrace, Mary Halim
dc.contributor.authorTherrien, Jean-Philippe
dc.contributor.authorValacchi, Giuseppe
dc.contributor.authorLila, Mary Ann
dc.date.accessioned2021-12-15T14:20:32Z
dc.date.available2021-12-15T14:20:32Z
dc.date.issued2021
dc.description.resumoThe present study investigated the effect of spray-dried algae-rosemary particles against pollution-induced damage using ex-vivo human biopsies exposed to diesel engine exhaust (DEE). For this, the complexation of hydroalcoholic rosemary extract with Chlorella (RCH) and Spirulina (RSP) protein powders was conducted. The process efficiency and concentration of rosmarinic acid (RA), carnosic acid (CA), and carnosol (CR) phenolic compounds of both products were compared. The RSP spray-dried production was more efficient, and RSP particles presented higher CR and CA and similar RA concentrations. Therefore, spray-dried RSP particles were prioritized for the preparation of a gel formulation that was investigated for its ability to mitigate pollution-induced skin oxinflammatory responses. Taken altogether, our ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts (4HNE-PA) and active matrix metalloproteinase-9 (MMP-9) as well as by limiting the loss of filaggrin induced by DEE exposure. Our results suggest that the topical application of spirulina-rosemary gel is a good approach to prevent pollution-induced skin aging/damagept_BR
dc.identifier.citationRoberta Correia; PAMBIANCHI, E.; PECORELLI, A.; GRACE, MARY H.; THERRIEN, J.; VALACCHI, G.; LILA, MARY ANN. Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage. MOLECULES, v. 26, p. 3781, 2021. Disponível em: https://www.mdpi.com/1420-3049/26/13/3781. Acesso em: 04 nov. 2021. https://doi.org/10.3390/molecules26133781pt_BR
dc.identifier.doi10.3390/molecules26133781
dc.identifier.issn1420-3049
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45376
dc.languageenpt_BR
dc.publisherMDPIpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectCosmeceuticalspt_BR
dc.subjectPollutionpt_BR
dc.subjectPhytochemicalspt_BR
dc.subjectHerbspt_BR
dc.titleNovel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damagept_BR
dc.typearticlept_BR

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