Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol

dc.contributor.authorMaciel, Bruna Leal Lima
dc.contributor.authorBona, Mariana Duarte
dc.contributor.authorTorres, Carlos Henrique de Medeiros
dc.contributor.authorLima, Severina Carla Vieira Cunha
dc.contributor.authorLima, Aldo Angelo Moreira
dc.date.accessioned2024-01-30T13:43:29Z
dc.date.available2024-01-30T13:43:29Z
dc.date.issued2021-05
dc.description.resumoIntroduction Intestinal barrier function is dependent on the structure and function of intestinal epithelial cells and paracellular pathway. The derangement of the intestinal barrier function can originate from conditions involving local and systemic chronic inflammation and metabolic diseases such as obesity and metabolic disorders. This study aims to describe a systematic review protocol investigating if obesity with or without metabolic syndrome is associated with an altered intestinal barrier function. Methods and analysis This protocol is guided by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. The databases to be searched are PubMed, Embase, Scopus, Science Direct and Web of Science. The systematic review will include original articles with adults and the elderly, who present obesity with or without metabolic syndrome, that address the intestinal barrier function. Two independent reviewers will perform study selection, data extraction and methodological quality assessment. Key information will be tabulated and a narrative synthesis will be conducted. The Grading of Recommendation, Assessment, Development and Evaluation framework will be used to assess the quality of evidence concerning the associations between intestinal barrier function and obesity with or without metabolic syndrome. The present protocol will assist in producing a systematic review that addresses if obesity with or without metabolic syndrome alters intestinal barrier function. Ethics and dissemination No ethical statement will be required. The results will be disseminated through a peerreviewed publication and conference presentationspt_BR
dc.identifier.citationBONA, Mariana Duarte; TORRES, Carlos Henrique de Medeiros; LIMA, Severina Carla Vieira Cunha; LIMA, Aldo Angelo Moreira; MACIEL, Bruna Leal Lima. Intestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocol. Bmj Open, [S.l.], v. 11, n. 5, p. 1-5, mai. 2021. DOI: 10.1136/bmjopen-2020-043959. Disponível em: https://bmjopen.bmj.com/content/11/5/e043959. Acesso em: 26 jan. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2020-043959
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/57451
dc.languageenpt_BR
dc.publisherBMJ Openpt_BR
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subjectIntestinal barrierpt_BR
dc.subjectObesitypt_BR
dc.subjectMetabolic syndromept_BR
dc.titleIntestinal barrier function in obesity with or without metabolic syndrome: a systematic review protocolpt_BR
dc.typearticlept_BR

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