Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta-gamma coupling during recall

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dc.contributor.authorGonzalez, Maria Carolina
dc.contributor.authorRadiske, Andressa
dc.contributor.authorOcazionez, Sergio Andrés Conde
dc.contributor.authorRossato, Janine Inez
dc.contributor.authorBevilaqua, Lia Rejane Muller
dc.contributor.authorCammarota, Martín Pablo
dc.date.accessioned2022-02-15T13:03:43Z
dc.date.available2022-02-15T13:03:43Z
dc.date.issued2022-01
dc.description.resumoHippocampal dopamine D1/D5 receptor-dependent destabilization is necessary for object recognition memory (ORM) updating through reconsolidation. Dopamine also regulates hippocampal theta and gamma oscillations, which are involved in novelty and memory processing. We found that, in adult male rats, ORM recall in the presence of a novel object, but not in the presence of a familiar one, triggers hippocampal theta-gamma coupling. Hippocampal theta-gamma coupling (hPAC) does not happen when ORM destabilization is prevented by blocking D1/D5 receptors, but artificial hPAC generation during recall in the presence of a familiar object enables the amnesic effect of reconsolidation inhibitors. Therefore, hPAC controls ORM destabilization, and its modulation could increase reconsolidation-based psychotherapy efficacypt_BR
dc.identifier.citationGONZALEZ, Maria Carolina; RADISKE, Andressa; CONDE-OCAZIONEZ, Sergio; ROSSATO, Janine I.; BEVILAQUA, Lia R. M.; CAMMAROTA, Martín. Reactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta–gamma coupling during recall. Learning & Memory, [S. l.], v. 29, n. 1, p. 1-6, jan. 2022. Doi: http://dx.doi.org/10.1101/lm.053482.121. Disponível em: http://learnmem.cshlp.org/content/29/1/1. Acesso em: 15 fev. 2022.pt_BR
dc.identifier.doi10.1101/lm.053482.121
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/45965
dc.languageenpt_BR
dc.publisherCold Spring Harbor Laboratorypt_BR
dc.rightsAttribution-NonCommercial 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by-nc/3.0/br/*
dc.subjectObject recognition memorypt_BR
dc.subjectamnesiapt_BR
dc.subjecthippocampal theta–gamma couplingpt_BR
dc.subjectreceptors, dopamine D1pt_BR
dc.subjectreceptors, dopamine D5pt_BR
dc.subjectmemory, short-Termpt_BR
dc.titleReactivation-dependent amnesia for object recognition memory is contingent on hippocampal theta-gamma coupling during recallpt_BR
dc.typearticlept_BR

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