Muscarinic and Nicotinic Modulation of Thalamo- Prefrontal Cortex Synaptic Pasticity In Vivo

Bueno-Junior, Lezio Soares; Lopes-Aguiar, Cleiton; Ruggiero, Rafael Naime; Romcy-Pereira, Rodrigo Neves; Leite, João Pereira

Muscarinic and Nicotinic Modulation of Thalamo- Prefrontal Cortex Synaptic Pasticity In Vivo

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dc.contributor.author	Bueno-Junior, Lezio Soares
dc.contributor.author	Lopes-Aguiar, Cleiton
dc.contributor.author	Ruggiero, Rafael Naime
dc.contributor.author	Romcy-Pereira, Rodrigo Neves
dc.contributor.author	Leite, João Pereira
dc.date.accessioned	2017-05-31T12:11:43Z
dc.date.available	2017-05-31T12:11:43Z
dc.date.issued	2012-10-30
dc.description.resumo	The mediodorsal nucleus of the thalamus (MD) is a rich source of afferents to the medial prefrontal cortex (mPFC). Dysfunctions in the thalamo-prefrontal connections can impair networks implicated in working memory, some of which are affected in Alzheimer disease and schizophrenia. Considering the importance of the cholinergic system to cortical functioning, our study aimed to investigate the effects of global cholinergic activation of the brain on MD-mPFC synaptic plasticity by measuring the dynamics of long-term potentiation (LTP) and depression (LTD) in vivo. Therefore, rats received intraventricular injections either of the muscarinic agonist pilocarpine (PILO; 40 nmol/mL), the nicotinic agonist nicotine (NIC; 320 nmol/mL), or vehicle. The injections were administered prior to either thalamic high-frequency (HFS) or low-frequency stimulation (LFS). Test pulses were applied to MD for 30 min during baseline and 240 min after HFS or LFS, while field postsynaptic potentials were recorded in the mPFC. The transient oscillatory effects of PILO and NIC were monitored through recording of thalamic and cortical local field potentials. Our results show that HFS did not affect mPFC responses in vehicle-injected rats, but induced a delayed-onset LTP with distinct effects when applied following PILO or NIC. Conversely, LFS induced a stable LTD in control subjects, but was unable to induce LTD when applied after PILO or NIC. Taken together, our findings show distinct modulatory effects of each cholinergic brain activation on MD-mPFC plasticity following HFS and LFS. The LTP-inducing action and long-lasting suppression of cortical LTD induced by PILO and NIC might implicate differential modulation of thalamo-prefrontal functions under low and high input drive.	pt_BR
dc.identifier.citation	Bueno-Junior LS, Lopes-Aguiar C, Ruggiero RN, Romcy-Pereira RN, Leite JP (2012) Muscarinic and Nicotinic Modulation of Thalamo-Prefrontal Cortex Synaptic Pasticity In Vivo. PLoS ONE 7(10): e47484. doi:10.1371/journal.pone.0047484	pt_BR
dc.identifier.issn	1932-6203
dc.identifier.uri	https://repositorio.ufrn.br/jspui/handle/123456789/23261
dc.language	eng	pt_BR
dc.rights	Acesso Aberto	pt_BR
dc.subject	Muscarinic	pt_BR
dc.subject	Nicotinic	pt_BR
dc.subject	Thalamo- Prefrontal Cortex	pt_BR
dc.subject	Pasticity	pt_BR
dc.subject	Synaptic	pt_BR
dc.title	Muscarinic and Nicotinic Modulation of Thalamo- Prefrontal Cortex Synaptic Pasticity In Vivo	pt_BR
dc.type	article	pt_BR