Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation

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dc.contributor.authorAlmeida Filho, Daniel Gomes de
dc.contributor.authorKoike, Bruna Del Vechio
dc.contributor.authorBillwiller, Francesca
dc.contributor.authorFarias, Kelly Soares
dc.contributor.authorSales, Igor Rafael Praxedes de
dc.contributor.authorLuppi, Pierre-Hervé
dc.contributor.authorRibeiro, Sidarta Tollendal Gomes
dc.contributor.authorQueiroz, Claudio Marcos Teixeira de
dc.date.accessioned2021-06-24T12:39:09Z
dc.date.available2021-06-24T12:39:09Z
dc.date.issued2021-06-22
dc.description.resumoHippocampal (HPC) theta oscillation during post-training rapid eye movement (REM) sleep supports spatial learning. Theta also modulates neuronal and oscillatory activity in the retrosplenial cortex (RSC) during REM sleep. To investigate the relevance of theta-driven interaction between these two regions to memory consolidation, we computed the Granger causality within theta range on electrophysiological data recorded in freely behaving rats during REM sleep, both before and after contextual fear conditioning. We found a training-induced modulation of causality between HPC and RSC that was correlated with memory retrieval 24 h later. Retrieval was proportional to the change in the relative influence RSC exerted upon HPC theta oscillation. Importantly, causality peaked during theta acceleration, in synchrony with phasic REM sleep. Altogether, these results support a role for phasic REM sleep in hippocampo-cortical memory consolidation and suggest that causality modulation between RSC and HPC during REM sleep plays a functional role in that phenomenonpt_BR
dc.identifier.citationALMEIDA-FILHO, Daniel Gomes de; KOIKE, Bruna del Vechio; BILLWILLER, Francesca; FARIAS, Kelly Soares; SALES, Igor Rafael Praxedes de; LUPPI, Pierre-Hervé; RIBEIRO, Sidarta; QUEIROZ, Claudio Marcos. Hippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidation. Scientific Reports, [S. l.], v. 11, n. 1, p. 13078. jun. 2021. Doi: http://dx.doi.org/10.1038/s41598-021-91659-5. Disponível em: https://www.nature.com/articles/s41598-021-91659-5. Acesso em: 24 jun. 2021.pt_BR
dc.identifier.doi10.1038/s41598-021-91659-5
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/32768
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectHippocampuspt_BR
dc.subjectTheta rhythmpt_BR
dc.subjectSleep, REMpt_BR
dc.subjectSpatial learningpt_BR
dc.subjectGyrus cingulipt_BR
dc.titleHippocampus-retrosplenial cortex interaction is increased during phasic REM and contributes to memory consolidationpt_BR
dc.typearticlept_BR

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