Low-dose LSD and the stream of thought: Increased Discontinuity of Mind, Deep Thoughts and abstract flow

dc.contributor.authorWießner, Isabel
dc.contributor.authorFalchi, Marcelo
dc.contributor.authorFontes, Fernanda Palhano Xavier de
dc.contributor.authorMaia, Lucas Oliveira
dc.contributor.authorFeilding, Amanda
dc.contributor.authorRibeiro, Sidarta Tollendal Gomes
dc.contributor.authorMota, Natália Bezerra
dc.contributor.authorAraujo, Draulio Barros de
dc.contributor.authorTófoli, Luís Fernando
dc.date.accessioned2021-10-28T18:53:31Z
dc.date.available2021-10-28T18:53:31Z
dc.date.issued2021-10-28
dc.description.resumoRationale: Stream of thought describes the nature of the mind when it is freely roaming, a mental state that is continuous and highly dynamic as in mind-wandering or free association. Classic serotonergic psychedelics are known to profoundly impact perception, cognition and language, yet their influence on the stream of thought remains largely unexplored. Objective: To elucidate the effects of LSD on the stream of thought. Methods: In a randomized, double-blind, placebo-controlled, crossover study, 24 healthy participants received 50 μg lysergic acid diethylamide (LSD) or inactive placebo. Mind-wandering was measured by the Amsterdam Resting State Questionnaire (ARSQ), free association by the Forward Flow Task (FFT) for three seed word types (animals, objects, abstract words). ARSQ and FFT were assessed at +0 h, +2 h, +4 h, +6 h, +8 h and +24 h after drug administration, respectively. Results: LSD, compared to placebo, induced different facets of mind-wandering we conceptualized as “chaos” (Discontinuity of Mind, decreased Sleepiness, Planning, Thoughts under Control, Thoughts about Work and Thoughts about Past), “meaning” (Deep Thoughts, Not Sharing Thoughts) and “sensation” (Thoughts about Odours, Thoughts about Sounds). LSD increased the FFT for abstract words reflecting an “abstract flow” under free association. Overall, chaos was strongest pronounced (+2 h to +6 h), followed by meaning (+2 h to +4 h), sensation (+2 h) and abstract flow (+4 h). Conclusions: LSD affects the stream of thought within several levels (active, passive), facets (chaos, meaning, sensation, abstractness) and time points (from +2 h to +6 h). Increased chaos, meaning and abstract flow at +4 h indicate the utility of a late therapeutic window in psycholytic therapy.pt_BR
dc.identifier.citationWIEßNER, Isabel; FALCHI, Marcelo; PALHANO-FONTES, Fernanda; MAIA, Lucas Oliveira; FEILDING, Amanda; RIBEIRO, Sidarta; MOTA, Natália Bezerra; ARAUJO, Draulio B.; TÓFOLI, Luís Fernando. Low-dose LSD and the stream of thought: increased discontinuity of mind, deep thoughts and abstract flow. Psychopharmacology, [S. l.], out. 2021. Doi: http://dx.doi.org/10.1007/s00213-021-06006-3. Disponível em: https://link.springer.com/article/10.1007/s00213-021-06006-3 . Acesso em: 28 out. 2021.pt_BR
dc.identifier.doi10.1007/s00213-021-06006-3
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/44732
dc.languageenpt_BR
dc.publisherSpringer Science and Business Media LLCpt_BR
dc.subjectLSDpt_BR
dc.subjectLysergic acid diethylamidept_BR
dc.subjectResting state cognitionpt_BR
dc.subjectMind-wanderingpt_BR
dc.subjectFree associationpt_BR
dc.subjectForward flowpt_BR
dc.subjectAbstract thinkingpt_BR
dc.subjectSemantic analysispt_BR
dc.titleLow-dose LSD and the stream of thought: Increased Discontinuity of Mind, Deep Thoughts and abstract flowpt_BR
dc.typearticlept_BR

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