Association between kidney function and Framingham risk score in an admixed population of Brazil

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dc.contributor.authorEvangelista, Karine Cavalcanti Maurício de Sena
dc.contributor.authorCosta, Brunna Soares Rodrigues
dc.contributor.authorFreitas, Erika Paula Silva
dc.contributor.authorCruz, Marina Sampaio
dc.contributor.authorDuarte, Victor Hugo Rezende
dc.contributor.authorSilva, Ananília Medeiros Gomes da
dc.contributor.authorSantos, Isabelle Cristina Clemente dos
dc.contributor.authorSantos, Jéssica Cavalcante dos
dc.contributor.authorRezende, Adriana Augusto
dc.contributor.authorSilbiger, Vivian Nogueira
dc.date.accessioned2024-08-26T20:52:26Z
dc.date.available2024-08-26T20:52:26Z
dc.date.issued2018-02
dc.description.resumoChronic kidney disease (CKD) increases cardiovascular disease (CVD) risk development. However, the mechanisms of reduced kidney function with CVD risk are unclear. This study aimed to investigate the association between kidney function and Framingham risk score (FRS) in participants with traditional cardiovascular risk factors and normal estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 m² in an admixed population of Brazil. The participants were divided into three groups according to FRS: low risk group with 0% to <10%, moderate risk group with ≥10% to 20% and high risk group with >20%. The eGFR was calculated using Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). Data from participants were collected by questionnaire, and blood and urine samples were collected to analyze biochemical markers. A total of 214 subjects aged 53±10 years old was collected. There were 77 individuals in low risk group, 59 in moderate risk group and 78 in high-risk group. Mean eGFRCKD-EPI was 89.39±15.05 mL/min/1.73 m² and 90.74±16.17 mL/min/1.73 m2 when race adjustment. The results indicated that there is an increasing the cardiovascular risk with a decreased of eGFR, conforming to a significant inverse correlation observed between eGFR and FRS with Spearman correlation (R²=-0.256, p<0.001; R²=-0.224, p=0.001, when adjusted for race). There was a statistically significant difference in eGFRCKD-EPI (p<0.001) and eGFRCKD-EPI with race adjustment (p=0.002) among risk groups. The data suggests that the reduction eGFR is associated with elevated FRS among Brazilian adults without CKD. Furthermore, the results suggest that race adjustment it’s not necessary in Brazilian populationpt_BR
dc.identifier.citationCOSTA, Brunna Soares Rodrigues; FREITAS, Erika Paula Silva; CRUZ, Marina Sampaio; DUARTE, Victor Hugo Rezende; SILVA, Ananília Medeiros Gomes da; SANTOS, Isabelle Cristina Clemente dos; SANTOS, Jéssica Cavalcante dos; REZENDE, Adriana Augusto; EVANGELISTA, Karine Cavalcanti Maurício Sena; SILBIGER, Vivian Nogueira. Association between kidney function and Framingham risk score in an admixed population of Brazil. Brazilian Journal of Pharmaceutical Sciences, [S.l.], v. 53, n. 3, p. 1-8, 1 fev. 2018. DOI: 10.1590/s2175-97902017000317185. Disponível em: https://www.scielo.br/j/bjps/a/DBtDNBTnDc7NKCypzwpqrfj/?lang=en. Acesso em: 25 jul. 2024.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/s2175-97902017000317185
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/59885
dc.languageenpt_BR
dc.publisherBrazilian Journal of Pharmaceutical Sciencespt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectChronic kidney diseasept_BR
dc.subjectCardiovascular diseasespt_BR
dc.subjectRisk factorspt_BR
dc.subjectGlomerular filtration ratept_BR
dc.subjectFramingham Risk Score - FRSpt_BR
dc.titleAssociation between kidney function and Framingham risk score in an admixed population of Brazilpt_BR
dc.typearticlept_BR

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