Association of l-arginine supplementation with markers of endothelial function in patients with cardiovascular or metabolic disorders: a systematic review and meta-analysis

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dc.contributor.authorFayh, Ana Paula Trussardi
dc.contributor.authorRodrigues-Krause, Josianne
dc.contributor.authorKrause, Mauricio
dc.contributor.authorRocha, Ilanna
dc.contributor.authorUmpierre, Daniel
dc.date.accessioned2023-11-28T23:19:02Z
dc.date.available2023-11-28T23:19:02Z
dc.date.issued2019-12
dc.description.resumoL-Arginine supplementation is a potential therapy for treating cardiovascular and metabolic diseases. However, the use of distinct L-arginine sources, intervened populations, and treatment regimens may have yielded confusion about their efficacy. This research constitutes a systematic review and meta-analysis summarizing the effects of L-arginine supplementation compared to placebo in individuals with cardiovascular disease (CVD), obesity, or diabetes. Eligibility criteria included randomized clinical trials and interventions based on oral supplementation of L-arginine with a minimum duration of three days; comparison groups consisted of individuals with the same disease condition receiving an oral placebo substance. The primary outcome was flow-mediated dilation, and secondary outcomes were nitrite/nitrate (NOx) rate and asymmetric dimethylarginine (ADMA). Statistical heterogeneity among studies included in the meta-analyses was assessed using the inconsistency index (I2). Fifty-four full-text articles from 3761 retrieved references were assessed for eligibility. After exclusions, 13 studies were included for data extraction. There was no difference in blood flow after post-ischemic hyperemia between the supplementation of L-arginine and placebo groups before and after the intervention period (standardized mean difference (SMD) = 0.30; 95% confidence intervals (CIs) = −0.85 to 1.46; I2 = 96%). Sensitivity analysis showed decreased heterogeneity when the studies that most favor arginine and placebo were removed, and positive results in favor of arginine supplementation were found (SMD = 0.59; 95% CIs = 0.10 to 1.08; I2 = 75%). No difference was found in meta analytical estimates of NOx and ADMA responses between arginine or placebo treatments. Overall, the results indicated that oral L-arginine supplementation was not associated with improvements on selected variables in these patients (PROSPERO Registration: CRD42017077289)pt_BR
dc.identifier.citationRODRIGUES-KRAUSE, Josianne; KRAUSE, Mauricio; ROCHA, Ilanna; UMPIERRE, Daniel; FAYH, Ana Paula Trussardi. Association of l-arginine supplementation with markers of endothelial function in patients with cardiovascular or metabolic disorders: a systematic review and meta-analysis. Nutrients, [S.l.], v. 11, p. 15, dez. 2018. DOI: 10.3390/nu11010015. Disponível em: https://www.mdpi.com/2072-6643/11/1/15. Acesso em: 28 nov. 2023.pt_BR
dc.identifier.doihttp://dx.doi.org/10.3390/nu11010015
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/55478
dc.languageenpt_BR
dc.publisherNutrientspt_BR
dc.rightsAttribution 3.0 Brazil*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/br/*
dc.subjectObesitypt_BR
dc.subjecttype 2 diabetespt_BR
dc.subjectcardiovascular diseasept_BR
dc.subjectnitric oxidept_BR
dc.subjectflow-mediated dilationpt_BR
dc.subjectasymmetric dimethylargininept_BR
dc.titleAssociation of l-arginine supplementation with markers of endothelial function in patients with cardiovascular or metabolic disorders: a systematic review and meta-analysispt_BR
dc.typearticlept_BR

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