Effect of diet intervention and oral zinc supplementation on metabolic control in berardinelli-seip syndrome

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dc.contributor.authorLeite, Lúcia Dantas
dc.contributor.authorRocha, Érica Dantas de Medeiros
dc.contributor.authorBaracho, Maria de Fatima Paiva
dc.contributor.authorSantos, Maria Gorete do Nascimento
dc.contributor.authorAraújo, Dina Maria de
dc.contributor.authorFrança, Mardone Cavalcanti
dc.contributor.authorSilva, Carlos Antônio Bruno da
dc.contributor.authorAlmeida, Maria das Graças
dc.contributor.authorRezende, Adriana Algusto
dc.contributor.authorMarchini, Júlio Sérgio Marchini
dc.contributor.authorBrandão Neto, José
dc.contributor.authorIDhttps://orcid.org/0000-0002-8061-7048pt_BR
dc.date.accessioned2024-12-02T23:15:26Z
dc.date.available2024-12-02T23:15:26Z
dc.date.issued2010
dc.description.resumoBackground/Aims: Berardinelli-Seip syndrome (BSS), also termed congenital generalized lipodystrophy or congenital generalized lipoatropic diabetes, is a rare autosomal recessive disease characterized by the nearly complete absence of metabolically active adipose tissue from birth, extreme insulin resistance, diabetes mellitus, and hepatomegaly. The aim of this study was to evaluate the effect of diet intervention and oral zinc supplementation on the metabolic control of BSS patients. Methods: During a 3-month period, 10 BSS patients received individualized diets and oral zinc supplementation. Food intake, clinical laboratory parameters, serum zinc and leptin, and plasma C-peptide concentrations were evaluated at the beginning of the study and after 3 months. Results: At the beginning of the study, all patients had elevated energy, protein, total fat, carbohydrate, calcium, iron, and zinc intakes. After 3 months, all of these parameters had decreased. Total fiber intakes remained low before and after diet intervention and oral zinc supplementation, and plasma levels of fasting glucose remained high. In contrast, glycated hemoglobin decreased significantly. Plasma leptin, C-peptide, and serum zinc levels increased during venous zinc tolerance testing, but there were no significant differences between the 2 curves obtained before and after diet intervention and oral zinc supplementation. Conclusions: Diet intervention and oral zinc supplementation were effective at controlling energy consumption, macronutrients, and glycated hemoglobin. Zinc likely acts as an adjunct therapy, thereby improving the effectiveness of leptin.pt_BR
dc.identifier.citationROCHA, Érica Dantas de Medeiros ; LEITE, Lúcia Dantas ; BARACHO, Maria de Fatima Paiva; SANTOS, Maria Gorete do Nascimento; ARAÚJO, Dina Maria de; FRANÇA, Mardone Cavalcanti; SILVA, Carlos Antônio Bruno da; ALMEIDA, Maria das Graças; REZENDE, Adriana Algusto; MARCHINI, Júlio Sérgio Marchini; BRANDÃO NETO, José. Effect of Diet Intervention and Oral Zinc Supplementation on Metabolic Control in Berardinelli-Seip Syndrome. Annals of Nutrition & Metabolism, v. 57, p. 9-17, 2010. Citações:12|12. DOI: https://doi.org/10.1159/000313932. Disponível em: https://doi.org/10.1159/000313932. Acesso em 18 out. 2024.pt_BR
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/60717
dc.languageenpt_BR
dc.publisherAnnals of Nutrition and Metabolismpt_BR
dc.subjectDiet interventionpt_BR
dc.subjectFood intakept_BR
dc.subjectZinc supplementationpt_BR
dc.subjectVenous zinc tolerance testpt_BR
dc.subjectBerardinelli-Seip syndromept_BR
dc.titleEffect of diet intervention and oral zinc supplementation on metabolic control in berardinelli-seip syndromept_BR
dc.typearticlept_BR

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