Nitroprusside single-dose prevents the psychosis-like behavior induced by ketamine in rats for up to one week

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dc.contributor.authorMaia-de-Oliveira, Joao Paulo
dc.contributor.authorSoares, Bruno Lobão
dc.contributor.authorRamalho, Thais
dc.contributor.authorGavioli, Elaine C.
dc.contributor.authorSoares, Vanessa Paula
dc.contributor.authorTeixeira, Leslie
dc.contributor.authorBaker, Glen B.
dc.contributor.authorDursun, Serdar M.
dc.contributor.authorHallak, Jaime E.C.
dc.date.accessioned2022-10-25T22:33:45Z
dc.date.available2022-10-25T22:33:45Z
dc.date.issued2015-03
dc.description.resumoRecently, we found a rapid and long-lasting improvement of symptoms in schizophrenic patients on antipsychotics after a single four-hour infusion of sodium nitroprusside (SNP), a nitric oxide (NO) donor with a short half-life. This improvement persisted for up to 4 weeks. Because these patients remained on antipsychotics after infusion of SNP was finished, the question arises about whether this improvement was due to SNP itself. We have now investigated whether SNP, alone, can produce preventive antipsychotic effects in rats treated with ketamine (KET). 56 adult rats divided into 7 groups were infused with SNP 4 mg/kg, KET 25 mg/kg, or saline as follows: group1 — saline, group2 — SNP, group3 — KET, group4 — KET 12 h after SNP, group5 — KET 1 day after SNP, group6 — KET 2 days after SNP, and group7 — KET 1 week after SNP. The animals were filmed in an open field arena for 30 min and the videos were later analyzed by ANY-Maze software to measure activity and stereotypy. SNP significantly prevented the emergence of hyperactivity induced by KET when it was administered for up to 1 week before KET, and prevented the emergence of stereotypies when it was administered for up to 1 day before KET. These findings in rats, which have an even faster metabolic rate than humans, suggest that the long-lasting effects observed in our clinical trial with SNP in humans could have been due to SNP itself, and indicate for the first time that SNP may present preventive antipsychotic effects.pt_BR
dc.identifier.citationMAIA-DE-OLIVEIRA, Joao Paulo et al. Nitroprusside single-dose prevents the psychosis-like behavior induced by ketamine in rats for up to one week. Schizophrenia research, v. 162, n. 1-3, p. 211-215, 2015. Disponível em: <http://www.schres-journal.com/article/S0920-9964(14)00768-3/fulltext>. Acesso em: 23 mar. 2018.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.schres.2014.12.035
dc.identifier.issn1573-2509
dc.identifier.urihttps://repositorio.ufrn.br/handle/123456789/49630
dc.languageenpt_BR
dc.publisherElsevierpt_BR
dc.rightsAcesso Abertopt_BR
dc.subjectSchizophreniapt_BR
dc.subjectSodium nitroprussidept_BR
dc.subjectNitric oxidept_BR
dc.subjectKetaminept_BR
dc.titleNitroprusside single-dose prevents the psychosis-like behavior induced by ketamine in rats for up to one weekpt_BR
dc.typearticlept_BR

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